Sökning: "asymmetric synthesis"

Visar resultat 11 - 15 av 159 avhandlingar innehållade orden asymmetric synthesis.

  1. 11. Asymmetric catalysis : ligand design and microwave acceleration

    Författare :Ulf Bremberg; KTH; []
    Nyckelord :;

    Sammanfattning : This thesis deals partly with the design and synthesis ofligands for use in asymmetric catalysis, and partly with theapplication of microwave heating on metal-based asymmetriccatalytic reactions.Enantiomerically pure pyridyl alcohols and bipyridylalcohols were synthesized from the chiral pool for future usein asymmetric catalysis. LÄS MER

  3. 12. Development of an Asymmetric Synthesis of Glionitrin A and B

    Författare :Niels Koning; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; total synthesis; glionitrin; natural products; asymmetric synthesis; organocatalysis; C-H activation; epidithiodiketopiperazine; sulfenylation;

    Sammanfattning : In this thesis, studies in the chemical synthesis of the dithiodiketopiperazine natural products (—)-glionitrin A and B are described.In Chapter 2, a synthesis of the indoline-fused 2,5-diketopiperazine core of glionitrin A and B using a C-H activation approach is described. LÄS MER

  4. 13. Synthesis and Applications of P-Chirogenic and Axially Chiral P,N-Phosphines as Ligands and Organocatalyst

    Författare :Kristian Andersson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; phosphoramidite; organocatalysis; aminophosphine; Nicholas reaction; asymmetric synthesis; phosphine; asymmetric hydrogenation; modular synthesis; P-chirogenic;

    Sammanfattning : This thesis deals with the enantioselective synthesis of chiral mixed phosphorous/nitrogen compounds and some of their applications in asymmetric synthesis. For the most part, the compounds are P-chirogenic, with the chirality centered on the phosphorous atom. The last part of the thesis deals with axially chiral phosphoramidites. LÄS MER

  5. 14. Enzyme- and Transition Metal-Catalyzed Asymmetric Transformations : Application of Enzymatic (D)KR in Enantioselective Synthesis

    Författare :Richard Lihammar; Jan-Erling Bäckvall; Wolfgang Kroutil; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Dynamic Kinetic Resolution; Kinetic Resolution; Enzyme Catalysis; Asymmetric Synthesis; organisk kemi; Organic Chemistry;

    Sammanfattning : Dynamic kinetic resolution (DKR) is a powerful method for obtaining compounds with high optical purity. The process relies on the combination of a kinetic resolution with an in situ racemization. LÄS MER

  7. 15. New Methods for the Synthesis of Vicinal Stereocenters : Palladium-Catalyzed Domino Reactions and Asymmetric Transfer Hydrogenation

    Författare :Brinton Seashore-Ludlow; Somfai Peter; Kevin Booker-Milburn; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; asymmetric synthesis; domino reactions; palladium-catalyzed reactions; oxindoles; amino alcohols;

    Sammanfattning : In this thesis the synthesis of vicinal stereocenters is investigated in two distinct contexts, namely the construction of 3,3-disubstituted oxindoles and the synthesis of b-hydroxy-a-amino acids. Both scaffolds are prevalent in a range of natural products and biologically relevant compounds and, therefore, methods for their synthesis are of great import. LÄS MER