Sökning: "astrocytoma"
Visar resultat 16 - 20 av 24 avhandlingar innehållade ordet astrocytoma.
16. Functional studies of the Quaking gene : Focus on astroglia and neurodevelopment
Sammanfattning : The RNA-binding protein Quaking (QKI) plays a fundamental role in post-transcriptional gene regulation during mammalian nervous system development. QKI is well known for advancing oligodendroglia differentiation and myelination, however, its functions in astrocytes and embryonic central nervous system (CNS) development remain poorly understood. LÄS MER
17. lmproving diagnosis of central nervous system tumours using genetic and epigenetic tools
Sammanfattning : Brain tumor diagnostics has traditionally been based on histopathology stains. The introduction of immunohistochemistry stains resulted in improved ability to classify these often devastating tumors. The understanding of molecular markers in central nervous system tumors has improved substantially in recent decades. LÄS MER
18. Roles of the transient receptor potential channels and the intracellular Ca2+ channels in Ca2+ signaling in the beta-cells
Sammanfattning : Previous studies from our group reported that pancreatic β-cells express ryanodine receptors (RyRs) that can mediate Ca2+-induced Ca2+ release (CICR). The full consequences of the activation of RyRs on Ca2+ signaling in these cells, however, remained unclear. LÄS MER
19. Neural Progenitor Cells in malignancy and injury of the brain. A Trojan Horse fro gliomas?
Sammanfattning : Gliomas are neoplasms arising in the central nervous system (CNS), and constitute the most common primary brain tumor. They are classified depending on the grade and morphology, from grade I, pilocytic astrocytoma, to grade IV, glioblastoma multiforme (GBM). Glioblastomas constitute a great challenge in treatment due to their disseminating nature. LÄS MER
20. p16INK4A and p15INK4B in senescence, immortalization and cancer : gene transfer by adenovirus vectors
Sammanfattning : The astrocytic gliomas are the most common form of brain tumors in humans. The malignant progression from low grade (astrocytoma, grade II) to high-grade (glioblastoma multiforme, grade, IV) astrocytomas is well documented and is accompanied by an increasing number of genetic aberrations. LÄS MER