Sökning: "astrocytes"

Visar resultat 16 - 20 av 242 avhandlingar innehållade ordet astrocytes.

  1. 16. Anti-epileptic and neuroprotective mechanisms by Topiramate and Levetiracetam evaluated in primary cultures

    Författare :Mikael Ängehagen; Göteborgs universitet; []
    Nyckelord :calcium imaging; phosphorylation; kainate; glutamate; caffeine; cerebral cortex; hippocampus; field potentials; neurons; astrocytes;

    Sammanfattning : The aim of this thesis was to evaluate plausible intracellular mechanisms of action for antiepileptic drugs, Topiramate (TPM) and Levetiracetam (LEV), and to investigate if TPM possesses neuroprotective properties. The thesis is based on results from calcium imaging, immunohistochemical stainings, viability tests, and Western blot using primary cortical or hippocampal cultures, or hippocampal brain slices. LÄS MER

  3. 17. On the Regulation of the Serine Protease t-PA and its Inhibitor PAI-1 in the Brain

    Författare :Karin Hultman; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gene expression; astrocytes; blood-brain barrier; plasminogen activator inhibitor type-1; polymorphisms; protease nexin-1; tissue-type plasminogen activator; transcriptional regulation;

    Sammanfattning : The serine protease tissue-type plasminogen activator (t-PA) is the main fibrinolytic enzyme in the vascular system, and thus plays a critical role in the dissolution of thrombi. In recent years, researchers have focused on its role within the brain, where t-PA has been shown to participate in a number of physiological and pathophysiological processes, including various aspects of synaptic plasticity and neurodegeneration. LÄS MER

  4. 18. Assessment of precursor cell proliferation in normal and injured adult mammalian brains

    Författare :Hong Zhu; Göteborgs universitet; []
    Nyckelord :6-OHDA; astrocytes; cell proliferation; neural stem cells; ; neurogenesis; precursor cells; seizure; SVZ-OB pathway;

    Sammanfattning : In the adult mammalian brain, new neurons are generated from neural stem cells (NSCs) which reside in the subventricular zone (SVZ) of the lateral ventricle wall and in the subgranular zone (SGZ) of the dentate gyrus (DG) in the hippocampus. The biology of persistent NSCs in the adult brain is poorly understood. LÄS MER

  5. 19. On dopamine neurons : nerve fiber outgrowth and L-DOPA effects

    Författare :Sara af Bjerkén; Ingrid Strömberg; Kathy Steece-Collier; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopamine; nerve fiber outgrowth; astrocytes; ventral mesencephalon; GDNF; L-DOPA; L-DOPA induced dyskinesia; Neurobiology; Neurobiologi;

    Sammanfattning : Parkinson’s disease is a disorder mainly characterized by progressive degeneration of dopamine producing neurons in the substantia nigra of the midbrain. The most commonly used treatment strategy is to pharmacologically restore the lost function by the administration of the dopaminergic precursor L-DOPA. LÄS MER

  7. 20. Impulse noise and brain injury. An experimental study in rats

    Författare :Annette Säljö Moberg; Göteborgs universitet; []
    Nyckelord :apoptosis; astrocytes; brain injury; blast; c-Fos; c-Jun; c-Myc; impulse noise; ; neurons; neurofilament; NSE; rat and S-100;

    Sammanfattning : Abstract. Pressure waves, experienced as impulse noise, affect many body organs, although most attention has been paid to the inner ear. Impulse noise is produced by e.g. LÄS MER