Avancerad sökning

Hittade 4 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Clinical studies of asthma phenotypes focusing on the role of the leukotrienes

    Författare :Per Gyllfors; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :>asthma; aspirin intolerance; leukotrienes; leukotriene D4 responsiveness; methacholine responsiveness; exhaled nitric oxide;

    Sammanfattning : Inflammation in the airways in connection to asthma is a complex phenomenon and the mechanisms underlying the associated clinical symptoms involve the interaction of many different kinds of cells and mediators, giving rise to different phenotypes. The aim of the present thesis was to investigate the molecular and cellular mechanisms that results in two of these phenotypes, i. LÄS MER

  3. 2. On the role of PGD2 metabolites as markers of mast cell activation in asthma

    Författare :Siobhán O'Sullivan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prostaglandin D2 (PGD2) is the major cyclooxygenase metabolite of arachidonic acid released after stimulation of mast cells. Prostaglandin D2, itself is a very unstable compound, therefore, quantitative determination of PGD2 is an unreliable indicator of its own endogenous production. LÄS MER

  4. 3. Non-invasive analysis of leukotrienes as biomarkers of airway inflammation : method development and clinical applications

    Författare :Flora Gaber; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Airway inflammation; aspirin-intolerant asthma; biomarker; exhaled breath condensate; FENO; induced sputum; leukotrienes; 5-lipoxygenase; non-invasive analysis; saliva;

    Sammanfattning : Asthma and chronic obstructive pulmonary disease (COPD) are two common diseases characterized by chronic airway inflammation, but the inflammation in asthma is different from the one in COPD. In addition, asthma is a heterogeneous disease presenting with many different phenotypes (e.g. LÄS MER

  5. 4. Clinical studies on the role of eicosanoids in the asthmatic airway inflammation

    Författare :Kameran Daham; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The underlying mechanisms in the asthmatic airway inflammation involve the interaction between different cells and mediators that consequently result in different clinical phenotypes. The aim of this thesis was to investigate the impact of inflammatory mediators, with emphasis on eicosanoids, on the inflammatory and functional airway responses under basal and triggered conditions in subjects with asthma, in particular ASA/NSAID-intolerant and allergic phenotypes. LÄS MER