Sökning: "aspirin-intolerant asthma"
Hittade 4 avhandlingar innehållade orden aspirin-intolerant asthma.
Sammanfattning : Inflammation in the airways in connection to asthma is a complex phenomenon and the mechanisms underlying the associated clinical symptoms involve the interaction of many different kinds of cells and mediators, giving rise to different phenotypes. The aim of the present thesis was to investigate the molecular and cellular mechanisms that results in two of these phenotypes, i. LÄS MER
Sammanfattning : Prostaglandin D2 (PGD2) is the major cyclooxygenase metabolite of arachidonic acid released after stimulation of mast cells. Prostaglandin D2, itself is a very unstable compound, therefore, quantitative determination of PGD2 is an unreliable indicator of its own endogenous production. LÄS MER
3. Non-invasive analysis of leukotrienes as biomarkers of airway inflammation : Method development and clinical applications
Sammanfattning : Asthma and chronic obstructive pulmonary disease (COPD) are two common diseases characterized by chronic airway inflammation, but the inflammation in asthma is different from the one in COPD. In addition, asthma is a heterogeneous disease presenting with many different phenotypes (e.g. LÄS MER
Sammanfattning : The underlying mechanisms in the asthmatic airway inflammation involve the interaction between different cells and mediators that consequently result in different clinical phenotypes. The aim of this thesis was to investigate the impact of inflammatory mediators, with emphasis on eicosanoids, on the inflammatory and functional airway responses under basal and triggered conditions in subjects with asthma, in particular ASA/NSAID - intolerant and allergic phenotypes. LÄS MER