Sökning: "aspartate"

Visar resultat 11 - 15 av 113 avhandlingar innehållade ordet aspartate.

1. 11. Physiological aspects of cochlear excitation and neurotransmitter release

   Författare :Wanje Jäger; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cochlea; cochlear microphonics; summating potential; vibratory response; tetracaine; aspartate; glutarnate; neurotransmitter; noise; hearing loss;

   Sammanfattning : Using an in vitro model of the guinea pig, the temporal bone preparation, cochlear physiology was studied. By perfusion of the scala tympani with oxygenated culture medium, the responses of the hearing organ to sound stimuli were maintained over several hours and the functional state was followed by monitoring the electrophysiological parameters cochlear microphonics (CM) and summating potential (SP). LÄS MER

3. 12. Spinal cord stimulation in neuropathy : experimental studies of biochemistry and behaviour

   Författare :Jian-Guo Cui; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Neuropathic pain; mononeuropathy; GABA; glutamate; aspartate; galanin; neuropeptide Y; adenosine; spinal cord stimulation;

   Sammanfattning : Neuropathic pain, presenting with cutaneous hypersensitivity, i.e. allodynia, dysesthesia and hyperalgesia, is often difficult to manage with pharmacotherapy, but may be effectively alleviated by electric spinal cord stimulation (SCS). However, the mode of action of SCS is still poorly understood. LÄS MER

4. 13. On amino acid neurotransmitters in the spinal cord motor nuclei

   Författare :Göran Örnung; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :neurotransmitter; aspartate; glutamate; GABA. glycine; homocysteate; taurine; ultrastructure; freeze-substitution; immunocytochemistry; bouton; synaptic input; motoneuron; strech reflex; spinal cord; cat. rat;

   Sammanfattning : Using pre- and post-embedding immunocytochemistry, the distribution of six amino acid neurotransmitter candidates, with special reference to y-amino-butyric acid (GABA), glycine and glutamate was examined in boutons apposing somata and dendrites in the lumbar motor nuclei of the cat spinal cord. The monosynaptic connection between muscle spindle I a afferents and motoneurons regarding content of neuroactive amino acid and complement of amino acid receptors in the postsynaptic membrane was studied in the rat. LÄS MER

5. 14. A pharmacokinetic and pharmacodynamic study of an antiepileptic drug (lamotrigine) in young patients with drug-resistant generalized epilepsy

   Författare :Ann-Sofie Eriksson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :High-performance liquid chromatography; Antiepileptic drugs; Therapeutic drug monitoring; Lamotrigine; Carbamazepine; Epilepsy; Children; Lennox-Gastaut; Efficacy; CSF; [gamma]aminobuturic acid; Glutamate; Aspartate; Glycine; EEG;

   Sammanfattning : The purpose of the present study was to investigate the safety and efficacy of lamotrigine in young patients with drug-resistant generalised epilepsy. This group of patients is difficult to study due to a high seizure frequency, comorbidity and the frequent use of polytherapy. LÄS MER

7. 15. Perinatal asphyxia in the rat : a morphological and functional analysis of the dopamine systems and dopamine-mediated behaviours in a novel experimental model

   Författare :Yong Chen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Rat; Perinatal asphyxia; Dopamine; Noradrenaline; Dopamine receptors; Substantia nigra; Ventral tegmental area; Striatum; Accumbens nucleus; Locomotor activity; Attention disorders; bFGF; Fos; pH; pyruvate; lactate; glutamate; aspartate.;

   Sammanfattning : Asphyxia during labour in the human being is one of the important paediatric complications which can lead to various degree of injuries in the central nervous system. No efficient therapy is available at present. LÄS MER