Sökning: "aryl hydrocarbon receptor"

Visar resultat 21 - 25 av 42 avhandlingar innehållade orden aryl hydrocarbon receptor.

  1. 21. Metabolism-dependent activation of food and environmental mutagens in endothelial cells

    Författare :Anita Annas; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

    Sammanfattning : The endothelial cells of blood vessels have been proposed as a target for toxic effects ofxenobiotics in the cardiovascular system. In the present studies, induction of cytochromeP450 1A (CYP1A) enzymes and metabolic activation of food and environmentalmutagens were examined in endothelial cells of rodents, birds, and humans. LÄS MER

  3. 22. Chemical mixtures and interactions with detoxification mechanisms and biomarker responses in fish

    Författare :Johanna Gräns; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Fish; AhR; CYP1A; PXR; Chemical mixtures; Chemical interaction; Biomarker;

    Sammanfattning : Several classes of anthropogenic chemicals are present as mixtures in the aquatic environment. However, information of how wildlife species, including fish, are affected by exposures to chemical mixtures is limited. LÄS MER

  4. 23. Male Subfertility and Prostate Cancer Risk: Epidemiological and Genetic Studies

    Författare :Yasir Ruhayel; Malmö Molekylärgenetisk reproduktionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytoplasmic and nuclear; Receptors; Prostatic neoplasms; genetic; Polymorphism; male; Infertility; Hypogonadism; Genetic association studies; Case–control studies; Androgens;

    Sammanfattning : Androgen action plays a pivotal role in male reproductive tract physiology and pathology. The androgen receptor (AR) gene harbors two codon repeat tracts: the CAG and GGN repeats, encoding corresponding amino acid sequences of variable length; the polyglutamine and polyglycine stretches, respectively. LÄS MER

  5. 24. In vitro bioassays: monitoring of bioactive chemical pollutants in food and food contact materials

    Författare :Erica Selin; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : We are continuously exposed to mixtures of known and unknown chemicals via our diet. The standard control program for food safety, at present, relies heavily on the chemical quantification of a limited number of chemicals with known toxic properties. LÄS MER

  7. 25. Chemical and bioanalytical characterisation of PAH-contaminated soils : identification, availability and mixture toxicity of AhR agonists

    Författare :Maria Larsson; Magnus Engwall; Jessika Hagberg; Peter Haglund; Örebro universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Polycyclic aromatic compounds; Soil; Risk assessment; Mixture studies; AhR-mediated activity; REPs; GC MS; H4IIE-luc bioassay; Chemistry; Kemi;

    Sammanfattning : Contaminated soils are a worldwide problem. Polycyclic aromatic hydrocarbons (PAHs) are common contaminants in soil at former industrial areas, especially at old gasworks sites, gas stations and former wood impregnation facilities. LÄS MER