Sökning: "artificial receptors"

Visar resultat 1 - 5 av 31 avhandlingar innehållade orden artificial receptors.

1. 1. Macrocyclic Carbohydrate/Amino Acid Hybrid Molecules - Synthesis and Evaluation as Artificial Receptors

   Författare :Johan Billing; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 3-dipolar cycloaddition; 3-triazoles; 2; 1; molecular recognition; artificial receptors; sugar amino acids; cyclic peptides; macrocycles; Organic chemistry; Organisk kemi;

   Sammanfattning : Methods were developed for the synthesis of three different types of macrocyclic carbohydrate/amino acid hybrid molecules. In the synthesis of the first type of macrocycles, a glucosamine derivative was oxidized at C6 and the obtained sugar amino acid was coupled to tripeptides. LÄS MER

3. 2. Synthesis and binding studies of 9,10-disubstituted anthracene and dibenzobarrelene-based receptors for recognition of carbohydrates in water

   Författare :Hans Grundberg; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; 2- trimethylsilyl ethyl sulfide; diastereoselectivity; water; carbohydrates; recognition; biomimetic; Artificial; receptor; Organic chemistry;

   Sammanfattning : Artificial, amfiphilic, and biomimetic receptors soluble in water were synthesized via attaching polar amino acids to hydrophobic back-bones possessing a surface suitable for hydrophobic interactions. The hydrophobic back-bones chosen in this thesis were anthracene and dibenzobarrelene structures. LÄS MER

4. 3. QCM-based sensing using biological and biomimetic interfaces

   Författare :Louise Elmlund; Ian Nicholls; Teodor Aastrup; Jesper Wiklander; Kristina Nilsson-Ekdahl; Håkan Andersson; Susanne Wikman; Alessandra Maria Bossi; Linnéuniversitetet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Quartz crystal microbalance; molecularly imprinted polymers; phage display; interactions; artificial receptors; recognition; selectivity; Kemi; Chemistry;

   Sammanfattning : The objective of this thesis was to explore novel approaches for studying molecular recognition at biological and biomimetic surfaces using the quartz crystal microbalance (QCM) biosensor technique. The first two papers focused on the synthesis and study of biotin selective polymer films prepared using the molecularly imprinted polymer (MIP) technique. LÄS MER

5. 4. Artificial receptors: New opportunities for the exploitation of molecularly imprinted polymers

   Författare :Lei Ye; Tillämpad biokemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Radioimmunoassay; Microsphere; Molecular imprinting; Drug determination; Cross-linking polymerisation; Combinatorial library; Chromatography; Chiral separation; Affinity adsorbent; Biosensor; Receptor; Biochemistry; Metabolism; Biokemi; metabolism; Biotechnology; Bioteknik;

   Sammanfattning : Molecular imprinting, method for creating artificial receptors that are mimics of biological antibodies and receptors, is based on the concept of creating substrate-specific recognition sites in polymeric matrices by means of template polymerisation. The polymeric receptors produced display favourable binding characteristics, such as high affinity and specificity towards the substrate molecules. LÄS MER

7. 5. Combinatorial Methodology. Screening for affinity specific ligands to biological and artificial receptors

   Författare :Margareta Krook; Tillämpad biokemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; peptide library; combinatorial; screening; phage display; affinity; DNA-interaction; chymotrypsin; peptide inhibitor; antibody; IgG; Fc; molecular imprinting; steroid; receptor; Biochemistry; Metabolism; Biokemi; Biotechnology; Bioteknik;

   Sammanfattning : Combinatorial screening methodology has been employed to select new affinity specific ligands to bilogical and artificial receptors. The screening methodology, in particular screening of combinatorial phage display peptide libraries against target molecules differing in function and shape, is focused upon. LÄS MER