Sökning: "artificial ECM"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden artificial ECM.

  1. 1. Functionalization of spider silk with affinity and bioactive domains via genetic engineering for in vitro disease diagnosis and tissue engineering

    Författare :Naresh Thatikonda; My Hedhammar; Hanna Dams Kozlowska; KTH; []
    Nyckelord :affinity domains; artificial ECM; basic fibroblast growth factor; functionalization; mammalian cell culture; micro-and nano arrays; partial spider silk; single chain variable fragments; Bioteknologi; Biotechnology;

    Sammanfattning : In the recent past, spider silk has drawn significant attention from researchers mainly due to its distinguished mechanical strength, elasticity, biocompatibility and biodegradability. Technological advancements in genetic engineering have resulted in methods for creation of partial spider silk proteins. LÄS MER

  3. 2. Infection biology of the plant pathogenic fungus Bipolaris sorokiniana

    Författare :Dace Apoga; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; microscopy; Hordeum vulgare; barley; virulence; prehelminthosporol; phytotoxins; proteins; adhesion; fimbriae; extracellular matrix; Helminthosporium sativum; Cochliobolus sativus; Plant pathogenic fungi; Bipolaris sorokiniana; two-dimensional gel electrophoresis; mass spectrometry; gas chromatography; Ecology; Ekologi;

    Sammanfattning : Bipolaris sorokiniana is a fungal pathogen causing severe disease mainly in wheat and barley worldwide. In this thesis two aspects of the infection process were investigated: the adhesion mechanism of the fungus and the role of the non-host specific phytotoxin prehelminthosporol (PHL) in the disease. Adhesion of B. LÄS MER

  4. 3. Extracellular matrix mimetic multi-functional scaffolds for tissue engineering and biomedical applications

    Författare :Ranjithkumar Ravichandran; Jaywant Phopase; Anthony Turner; Ann-Christine Albertsson; Linköpings universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Sammanfattning : Regeneration of functional tissues or complex organs via the combination of viable cells, biomimetic scaffolds, morphogenic factors, and external biophysical cues are the principle aims of Tissue Engineering (TE). TE relies on the use of artificial 3D scaffolds that can mimic the microenvironment of native tissue to harness the regenerative potential of cells. LÄS MER

  5. 4. Engraftment and tolerance induction in cellular therapy : focus on mesenchymal stromal cells

    Författare :Karin Ljung; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Different cell types have been employed in the search for a cellular therapy that is applicable for the treatment of heart failure. Remuscularization strategies using stem-cell-derived cardiomyocytes have been prone to arrhythmias. LÄS MER

  7. 5. Tumor Selective Antiproliferative Naphthoxylosides

    Författare :Ulrika Aili; Glykobiologigruppen; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glycosaminoglycan; proteoglycan; heparan sulfate; xyloside; naphthoxyloside; histone H3 acetylation;

    Sammanfattning : Proteoglycans (PG) are highly anionic macromolecules consisting of a core protein covalently substituted with long unbranched polysaccharide chains called glycosaminoglycans (GAGs). PGs are central components in multicellular organisms, and they may occur in the extracellular matrix (ECM), at the cell surface, or in the secretory pathway. LÄS MER