Sökning: "arterial input function"

Visar resultat 6 - 10 av 13 avhandlingar innehållade orden arterial input function.

  1. 6. Intracranial Pressure in Traumatic Brain Injury

    Författare :Sima Shahsavari; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Brain Swelling; Cerebral Autoregulation; Secondary Brain Injury; Traumatic Brain Injury; Cerebral Compliance; Intracranial Dynamics; Intracranial Pressure;

    Sammanfattning : Traumatic Brain Injury (TBI) continues to be a major problem worldwide. Today, intensive care of patients with TBI is mainely focused on preventing and treating secondary brain injuries. High pressure inside the intracranial cavity (ICP) has been found to be an important feature of disturbed cerebral dynamics and secondary injuries. LÄS MER

  3. 7. Nonlinear Mixed Effects Methods for Improved Estimation of Receptor Occupancy in PET Studies

    Författare :Matts Kågedal; Mats Karlsson; Andrew C Hooker; Gitte Knudsen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PET; positron emission tomography; receptor occupancy; nonlinear mixed effects; NONMEM; optimal design; dose finding; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : Receptor occupancy assessed by Positron Emission Tomography (PET) can provide important translational information to help bridge information from one drug to another or from animal to man. The aim of this thesis was to develop nonlinear mixed effects methods for estimation of the relationship between drug exposure and receptor occupancy for the two mGluR5 antagonists AZD9272 and AZD2066 and for the 5HT1B receptor antagonist AZD3783. LÄS MER

  4. 8. Abdominal Aortic Wall Mechanics - Stress, Strain and Stiffness in A Medical Perspective : An Experimental Study in Man

    Författare :Jerker Karlsson; Jan Engvall; Toste Länne; Jonas Stålhand; Carl-Johan Carlhäll; Magnus Cinthio; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Background:  The stiffness of the abdominal aorta is considered a significant factor affecting the morbidity and mortality of cardiovascular disease. Estimating vascular stiffness is an integral part in cardiovascular risk assessment. LÄS MER

  5. 9. Positron emission tomography : development, evaluation and application of quantification methods

    Författare :Pontus Plavén-Sigray; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Positron Emission Tomography (PET) is an imaging technique that allows for in vivo quantification of biochemical and physiological processes in the brain. Examples of targets in the brain that can be imaged using PET are dopamine receptors and the translocator protein 18kDa (TSPO). LÄS MER

  7. 10. Cerebral CT - and MRI perfusion: Techniques and clinical application in iNPH

    Författare :Doerthe Ziegelitz; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cerebral perfusion; idiopathic normal pressure hydrocephalus; computed tomography perfusion; dynamic suceptibility contrast MRI;

    Sammanfattning : Idiopathic normal pressure hydrocephalus (iNPH) is a disorder of the elderly, defined by slowly progressive impairment of gait and balance, cognitive decline, and incontinence. Disturbance of the cerebrospinal fluid (CSF) dynamics results in ventriculomegaly without intracranial pressure increase. LÄS MER