Sökning: "aquaporin 2"

Visar resultat 11 - 15 av 26 avhandlingar innehållade orden aquaporin 2.

  1. 11. Marginally hydrophobic transmembrane α-helices shaping membrane protein folding

    Författare :Tuuli Minttu Virkki de Marothy; Arne Elofsson; William Dowhan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane protein folding; hydrophobicity; translocon; transmembrane helix; marginally hydrophobic transmembrane helices; orientational preference; positive inside rule; aquaporin 1; Biochemistry; biokemi;

    Sammanfattning : Most membrane proteins are inserted into the membrane co-translationally utilizing the translocon, which allows a sufficiently long and hydrophobic stretch of amino acids to partition into the membrane. However, X-ray structures of membrane proteins have revealed that some transmembrane helices (TMHs) are surprisingly hydrophilic. LÄS MER

  3. 12. Biomarker Discovery in Tissue-specific Autoimmune Disease

    Författare :Nils Landegren; Olle Kämpe; Björn Dahlbäck; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Autoimmune diseases encompass a diverse group of disorders that collectively affect 5% of the population. Despite large clinical variability, autoimmune disorders share a common etiology in that they all develop from immune responses against self. LÄS MER

  4. 13. Regulation of Aquaporins by Proteins, Metal ions and Phosphate groups

    Författare :Stefan Kreida; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aquaporin-2; aquaporin-0; calmodulin; LIP5; phosphorylation; calcium; zinc; protein-protein interactions; aquaporin regulation; trafficking; gating;

    Sammanfattning : Aquaporins (AQPs) are membrane-bound intrinsic water channels that allow the passive diffusion of water and small solutes across cellular membranes. There are 13 highly conserved isoforms of these channels in human, which differ in specificity, regulation and localisation in cells and tissues. LÄS MER

  5. 14. AQUAPORINS: Production Optimization and Characterization

    Författare :Fredrik Öberg; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Aquaporins are water facilitating proteins embedded in the cellular membranes. Such channels have been identified in almost every living organism – including humans. They are vital molecules and their malfunction can lead to several severe disorders. LÄS MER

  7. 15. Preterm intraventricular haemorrhage - Effects of extracellular haemoglobin

    Författare :Snjolaug Sveinsdottir; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Intraventricular haemorrhage (IVH) is the most common brain lesion in preterm infants and is most commonly seen in the sickest children, with 15-20% of very preterm infants developing IVH. The mortality of infants with severe IVH is 20-50 % in the neonatal period and over 50 % of surviving infants develop post-haemorrhagic ventricular dilatation (PHVD) and 40-80 % develop severe neurological impairment, mainly cerebral palsy and mental retardation. LÄS MER