Sökning: "apostolos tsolakis"

Hittade 3 avhandlingar innehållade orden apostolos tsolakis.

  1. 1. Characterization of Endocrine Cells and Tumours in the Stomach

    Författare :Apostolos V. Tsolakis; Eva T. Janson; Mats Stridsberg; Guida M. Portela-Gomes; Ola Nilsson; Uppsala universitet; []
    Nyckelord :Oncology; ECL cells; ghrelin cells; gastric endocrine tumours; VMAT-2; ghrelin; obestatin; HDC; U-MeImAA; Onkologi;

    Sammanfattning : Enterochromaffin-like (ECL) and ghrelin cells, in the human gastric mucosa and in gastric endocrine tumours (GETs), were subclassified with respect to immunohistochemical reaction vs. vesicular monoamine transporter 2 (VMAT-2), ghrelin/obestatin, and histidine decarboxylase (HDC). LÄS MER

  3. 2. Novel Circulating and Tissue Biomarkers for Small Intestine Neuroendocrine Tumors and Lung Carcinoids

    Författare :Tao Cui; Valeria Giandomenico; Kjell Öberg; Apostolos V. Tsolakis; Marco Volante; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; small intestine neuroendocrine tumors; lung carcinoids; Ma2 autoantibodies; immunohistochemistry; olfactory receptor 51E1; blood samples; antibody suspension bead array; 小肠神经内分泌肿瘤，肺类癌，Ma2自身抗体，免疫组化，嗅觉受体蛋白51E1， 血液样本，抗体悬浮磁珠阵列; Endokrinologi och Diabetologi; Endocrinology and Diabetology; Lung Medicine; Lungmedicin; Molecular Biology; Molekylärbiologi; Oncology; Onkologi;

    Sammanfattning : Small intestine neuroendocrine tumors (SI-NETs) and lung carcinoids (LCs) are relatively indolent tumors, which originate from neuroendocrine (NE) cells of the diffuse NE system. Metastases can spread before diagnosis. Thus, potential cures become unavailable, which entitles new biomarker development. LÄS MER

  4. 3. Expression of Neuroendocrine Markers in Normal and Neoplastic Tissue with an Emphasis on Ghrelin and Obestatin

    Författare :Malin Grönberg; Eva Tiensuu Janson; Apostolos Tsolakis; Jan Saras; Mauro Papotti; Uppsala universitet; []
    Nyckelord :ghrelin; obestatin; neuroendocrine marker; immunohistochemistry; neuroendocrine tumors; breast cancer; mammary glands; MEDICINE; MEDICIN; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

    Sammanfattning : The aim of this thesis was to characterize the expression of the peptides ghrelin and obestatin, as well as other neuroendocrine markers in human normal tissues, in invasive breast cancer and a wide panel of neuroendocrine tumors (NETs). In normal tissues the expression of ghrelin and obestatin was mainly localized to the gastric mucosa, and in lesser extent in the remaining gastrointestinal tract, endocrine pancreas and mammary glands. LÄS MER