Sökning: "apoptosis. bcl-2"

Visar resultat 1 - 5 av 107 avhandlingar innehållade orden apoptosis. bcl-2.

  1. 1. Studies on the Bcl-2 Family of Apoptosis Regulators in the Nervous System

    Författare :Susanne Hamnér; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Bcl-2; Bcl-w; Bad; Apoptosis; Nervous system; Cerebellar granule cells; Sympathetic neurons; Neurovetenskap; Neurology; Neurologi; Developmental Neurosciences; medicinsk utvecklings- och neurobiologi;

    Sammanfattning : Apoptosis is a type of cell death with a specific morphology and molecular program, which is essential for the development of the nervous system. However, inappropriate cell death has been implicated in several neurodegenerative diseases. LÄS MER

  3. 2. Insight into the mitochondrial apoptotic pathway : The interplay of the pro-apoptotic Bax protein with oxidized phospholipids and its counterplayer, the pro-survival Bcl-2 protein

    Författare :Marcus Wallgren; Gerhard Gröbner; Marco Colombini; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; apoptosis; Bax; Bcl-2; CD; cell-free protein synthesis; DSC; membrane; mitochondria; oxidized phospholipids; reconstitution; solid state NMR; biologisk kemi; biological chemistry;

    Sammanfattning : Apoptosis plays a crucial role in multicellular organisms by preserving tissue homeostasis and removing harmful cells. The anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) and the pro-apoptotic Bcl-2-associated X protein (Bax) act as major regulators of the mitochondrial apoptotic pathway. LÄS MER

  4. 3. Regulation of apoptosis in human multiple myeloma

    Författare :Helena Spets; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; apoptosis; multiple myeloma; IL-6; Bcl-2; Fas; dexamethasone; IGF-I; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Multiple myeloma (MM) is a clonal expansion of malignant plasmablasts-plasma cells in the bone marrow. MM is slowly proliferating and an increased resistance to apoptosis may be crucial for the tumor progression. LÄS MER

  5. 4. Regulation of UV induced apoptosis in human melanocytes

    Författare :Cecilia Bivik; Inger Rosdahl; Karin Öllinger; Maria Shoshan; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; UV; melanocyte; lysosome; cathepsin; Bcl-2; Bax; Hsp70; JNK; Dermatology and venerology; Dermatologi och venerologi;

    Sammanfattning : Malignant melanoma arises from the pigment producing melanocytes in epidermis and is the most aggressive type of skin cancer. The incidence of malignant melanoma is increasing faster than any other type of cancer in white population worldwide, with a doubling rate every 10-20 years. LÄS MER

  7. 5. Molecular Studies of Mast Cell Migration and Apoptosis : Two Ways of Regulating Mast Cell Numbers at Sites of Inflammation

    Författare :Jessica Alfredsson; Gunnar Nilsson; Hans-Uwe Simon; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; mast cell; SCF; IL-3; FcεRI; migration; apoptosis; Bim; Bcl-2; Bcl-XL; Akt; FOXO; MAPK; Patologi; Pathology; Patologi;

    Sammanfattning : Upon activation mast cells release numerous proinflammatory mediators. With this feature, mast cells play an important role in host defense against pathogens, and are involved in tissue remodeling and wound healing. However, in cases of excessive inflammation the effects of mast cells are detrimental. LÄS MER