Sökning: "apoptos cancer"
Visar resultat 1 - 5 av 36 avhandlingar innehållade orden apoptos cancer.
1. Investigation of immune cell-derived factors as potential biomarkers in patients with colorectal cancer
Sammanfattning : Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer related death. It is a heterogeneous disease involving multiple molecular pathways that result in differing phenotypes. Individual variability in CRC susceptibility is influenced by genetic variation, such as single nucleotide polymorphisms (SNPs). LÄS MER
2. Role of Wnt-5a in breast cancer
Sammanfattning : Breast cancer is one of the most common cancer forms in the industrialized world. Only in Sweden, nearly 6000 women are diagnosed with breast cancer each year and 1/3 of them eventually succumb to the disease. LÄS MER
3. Cyclin A1 Expression and Regulation in Hematopoietic and Leukemic Cells
Sammanfattning : Increased expression of the cell cycle regulatory protein cyclin A1 has previously been detected in patients with acute myeloid leukemia (AML) and targeted overexpression of cyclin A1 in a transgenic mouse model initiated AML. The aim of this thesis was to further study the expression and regulation of cyclin A1 in hematopoietic cells. LÄS MER
4. Aggressive lymphoma
Sammanfattning : Aggressive lymphoma is a rapidly growing tumour of lymphocyte origin, potentially curable with chemotherapy. In a trial by the Nordic Lymphoma Group, 405 patients with aggressive lymphoma were included, and randomised to receive either the standard chemotherapy regimen, CHOP, or a weekly multidrug regimen, MACOP-B. LÄS MER
5. Endothelial and cardiac effects of 5-fluorouracil. An experimental and clinical study
Sammanfattning : The cytostatic drug 5-fluorouracil (5-FU) has been shown to affect both morphology and function of vascular endothelium. These effects could be part of the pathophysiology for 5-FU induced cardiotoxicity. The present thesis explores the mechanisms of this endothelial toxicity. LÄS MER