Sökning: "apolipoprotein e4"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden apolipoprotein e4.
1. The synaptic and neurobiological role of apolipoprotein E4 in models of Alzheimer's disease
Sammanfattning : .... LÄS MER
2. Apolipoprotein E and Alzheimer's diseases : signals and effects
Sammanfattning : Alzheimer's Disease (AD) is the most frequent cause of dementia in the elderly. A diagnosis of AD is confirmed post-mortem by the accumulation of neuritic plaques (NP) and neurofibrillary tangles (NFTs) in brain tissue. LÄS MER
3. Links between plasma apoE and glucose metabolism, brain insulin signaling, and synaptic integrity : Relevance to Alzheimer’s disease pathophysiology
Sammanfattning : Human apolipoprotein E (apoE) exists as three main isoforms called apoE2, apoE3, and apoE4, of which the E4 isoform is associated with increased Alzheimer’s disease (AD) risk. Brain glucose hypometabolism, linked to synaptic dysfunction, occurs years before symptom onset in AD, especially in APOEε4-carriers. LÄS MER
4. Apolipoprotein E and alpha-synuclein interactions, and their associations with neurodegenerative diseases
Sammanfattning : The apolipoprotein E gene (APOE) is expressed as three major isoforms, APOE ε2, ε3 and ε4 that encode the apoE2, E3 and E4 proteins, respectively. APOE ε4 is associated with an increased risk for age-related neurodegenerative diseases including Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB), and increases the risk of dementia in Parkinson’s disease (PD), however, the exact molecular mechanisms underpinning the associations between APOE ε4 and neurodegeneration are still unknown. LÄS MER
5. Studies on apolipoprotein E and high cholesterol diet as risk factors for neurodegeneration
Sammanfattning : Elevated level of plasma cholesterol is a well-established risk factor for cardiovascular disease, and emerging evidence suggest that it plays a role in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). The relations between dietary habits and neurodegeneration are complex, as the brain is selectively separated from peripheral circulation by the blood brain barrier (BBB). LÄS MER