Sökning: "apolipoprotein E gene"

Visar resultat 1 - 5 av 34 avhandlingar innehållade orden apolipoprotein E gene.

  1. 1. Peripheral apolipoprotein E and its emerging role in neurodegenerative disease

    Författare :Andreas Giannisis; Henrietta M. Nielsen; Kim Kultima; Johan Ankarklev; Cheryl Wellington; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; apolipoprotein E; humanized-liver mice; race; diet; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : The human apolipoprotein E gene (APOE) is polymorphic and coding for three common alleles; ε2, ε3, and ε4. Carriers of the ε4 allele are at a higher risk of developing sporadic late-onset Alzheimer’s Disease (AD). This association appears to be influenced by inherited traits, race, and sex. LÄS MER

  3. 2. Air pollution and dementia in a low exposure setting : the role of noise, olfaction, and theapoe gene

    Författare :John Andersson; Maria Nordin; Anna Oudin; Anna Sundström; Tom Russ; Umeå universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Air pollution; Road traffic; NOx; dementia; APOE; Alzheimer’s disease; Apolipoprotein E; olfaction; particulate matter; vascular dementia; odor identification; odor detection; Psychology; psykologi;

    Sammanfattning : Previous research indicates an association between air pollution exposure, and risk of dementia. Still, a number of factors that may play a role in this association remain to be explored. LÄS MER

  4. 3. Apolipoprotein E and Alzheimer's diseases : signals and effects

    Författare :Ángel Cedazo-Minguez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's Disease (AD) is the most frequent cause of dementia in the elderly. A diagnosis of AD is confirmed post-mortem by the accumulation of neuritic plaques (NP) and neurofibrillary tangles (NFTs) in brain tissue. LÄS MER

  5. 4. Apolipoprotein E and cholinergic enzymes : the interface in dementia

    Författare :Swetha Vijayaraghavan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main confirmed genetic risk factor for sporadic form of Alzheimer’s disease (AD) is apolipoprotein E (ApoE) ε4 allele (APOE4). ApoE protein aids in receptor ligand mediated transport, distribution and metabolism of fatty acids and cholesterol. LÄS MER

  7. 5. Prediction value of genetic and neuromarkers in blood and liquor in patients with severe traumatic brain injury

    Författare :Martin Öst; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic brain injury; outcome; NFL; GFAP; tau; β-amyloid; apolipoprotein E; biochemical neuromarkers;

    Sammanfattning : Background: Severe traumatic brain injury (sTBI) is the most common cause of mortality in young adults. sTBI induces variable brain damage, invisible in Computer Tomographic scans early post-trauma. Further, neurology is difficult to evaluate in sedated patients. LÄS MER