Sökning: "antivirals"

Visar resultat 1 - 5 av 27 avhandlingar innehållade ordet antivirals.

  1. 1. Early host cell interactions and antivirals against ocular adenoviruses

    Författare :Rickard Storm; Niklas Arnberg; Saw See Hong; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenovirus; Virus host interactions; Antivirals; Sialic acid; Integrins; Epidemic keratoconjuntivitis;

    Sammanfattning : Viruses are common causative agents of ocular infection among humans. Epidemic keratoconjuntivitis (EKC) is a severe and contagious ocular disease with reported outbreaks worldwide. It is estimated that this disease affects 20-40 million individuals every year, which leads to huge socioeconomic costs for the affected countries. LÄS MER

  3. 2. Cellular receptors for viruses with ocular tropism

    Författare :Emma C Nilsson; Niklas Arnberg; Eric J Kremer; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenovirus; picornavirus; receptors; antivirals; Virology; Virologi; molekylärbiologi; Molecular Biology; Infectious Diseases; infektionssjukdomar; mikrobiologi; Microbiology;

    Sammanfattning : Several viruses from different virus families are known to cause ocular infections, e.g. members of the Adenoviridae, Picornaviridae and the Herpesviridae families. These infections are spread by contact and in the case of adenoviruses (Ads) and picornaviruses they are also highly contagious. LÄS MER

  4. 3. Resistance to neuraminidase inhibitors in influenza A virus isolated from mallards

    Författare :Goran Orozovic; Björn Olsen; Johan Lennerstrand; Sigvard Olofsson; Linnéuniversitetet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; influenza; mallards; neuraminidase; PCR; sequencing; mutation; oseltamivir; zanamivir; resistance; NAI; antivirals; pandemic; Virology; Virologi; Molecular biology; Molekylärbiologi; Bioinformatics; Bioinformatik; Zoonotisk ekologi; Zoonotic Ecology; Virology; Virologi; Biokemi; Biochemistry;

    Sammanfattning : Influenza A virus belongs to the Orothomyxoviridae family of viruses and is one of the most common pathogens that cause infections of the respiratory tract. The aim of this thesis was to investigate if neuraminidase inhibitor (NAI) Tamiflu® (oseltamivir, OC) and Relenza® (zanamivir, ZA) - related resistance mutations exist in the neuraminidase (NA) gene of viruses collected from wild birds. LÄS MER

  5. 4. Discovery and evaluation of direct acting antivirals against hepatitis C virus

    Författare :Eldar Abdurakhmanov; Helena Danielson; David Frick; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Direct acting antivirals; Hepatitis C; NS3-4A protease; NS5B polymerase; structure-based drug discovery; fragment-based drug discovery; surface plasmon resonance; Biokemi; Biochemistry;

    Sammanfattning : Until recently, the standard therapy for hepatitis C treatment has been interferon and ribavirin. Such treatment has only 50% efficacy and is not well tolerated. The emergence of new drugs has increased the treatment efficacy to 90%. LÄS MER

  7. 5. Cell and organoid models to develop new antivirals and diagnostic methods for emerging viruses

    Författare :Aleksandra Pettke; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The ongoing global pandemic of severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) is only the latest reminder of the urgent need for new antiviral strategies and diagnostic tools to improve preparedness for emergence of new pathogenic RNA-viruses. A key obstacle for the development of antivirals and diagnostic tools has been the lack of good models to study RNA viruses. LÄS MER