Sökning: "antiviral response"

Visar resultat 21 - 25 av 96 avhandlingar innehållade orden antiviral response.

  1. 21. Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection

    Författare :Jesper Waldenström; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C virus; HCV; Inosine triphosphate pyrophosphatase; ITPA; interferon-λ4; IFNL4; ribavirin; interferon; PWID; IP-10;

    Sammanfattning : Hepatitis C virus (HCV) impacts on global health with around 70 million chronically infected worldwide. The infection increases the risk of cirrhosis and primary liver cancer. The treatment until 2013 has been based on interferon-α and ribavirin, but is now replaced by direct acting antivirals. LÄS MER

  3. 22. Immune modulation in chronic HBV and HCV infection

    Författare :Catharina Hultgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HBV; HBeAg; HCV; NS3; chronic infection; humoral cellular immune response; Th1 Th2 cells; proliferative response;

    Sammanfattning : Chronic viral hepatitis is a major health problem worldwide. The two major viral causes for chronic hepatitis are the hepatitis B (HBV) and C viruses (HCV). HBV is a DNA virus with a rather limited genetic variability whereas HCV is an RNA virus with a high genetic variability. LÄS MER

  4. 23. Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients

    Författare :Karin Lindahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hepatits C; ribavirin; pharmacokinetics; renal function; plasma concentration; anaemia; population pharmacokinetic analysis; peginterferon; sustained viral response;

    Sammanfattning : Chronic hepatitis C infection is a global health problem with 170 million patients infected. Hepatitis C virus (HCV) infection is a leading cause of end stage liver disease. Current antiviral treatment options available are not optimal either regarding cure of disease or risk of side effects. LÄS MER

  5. 24. Host-microbe interactions in coxsackievirus infection : focus on innate immunity

    Författare :Michael Hühn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Coxsackievirus group B (CVB) is a common virus that usually causes only mild symptoms in humans. However, occasionally these infections result in severe diseases like meningitis, myocarditis and pancreatitis. LÄS MER

  7. 25. The role of the type I interferons and viperin during neurotropic flavivirus infection

    Författare :Richard Lindqvist; Anna Överby Wernstedt; Daniel Ruzek; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TBEV; Flavivirus; Interferon; Neurotropic; Viperin;

    Sammanfattning : Flaviviruses are globally distributed pathogens that cause millions of human infections annually. One of the most detrimental outcomes of flavivirus infection is encephalitis, which is caused by neurotropic flaviviruses such as West Nile virus (WNV), Japanese encephalitis virus (JEV), and Tick-borne encephalitis virus (TBEV). LÄS MER