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Visar resultat 1 - 5 av 96 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Studies of Retroviral Reverse Transcriptase and Flaviviral Protease Enzymes as Antiviral Drug Targets : Applications in Antiviral Drug Discovery & Therapy

   Författare :Muhammad Junaid; Jarl ES Wikberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virus; enzymes; HIV AIDS; retroviral reverse transcriptase; flaviviral protease; NRTIs; proteochemometrics; drug resistance; DEN; JEV; NS2B H -NS3pro; antiviral; drug targets; drug discovery; drug therapy.; Farmakologi; Pharmacology;

   Sammanfattning : Viruses are a major threat to humans due to their unique adaptability, evolvability and  capability to control their hosts as parasites and genetic elements. HIV/AIDS is the third largest cause of death by infectious diseases in the world, and drug resistance due to the viral mutations is still the leading cause of treatment failure. LÄS MER

3. 2. Effects of Complement Opsonization of HIV on Dendritic Cells : and Implications for the Immune Response

   Författare :Rada Ellegård; Marie Larsson; Jorma Hinkula; Johan D Söderholm; William Paxton; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; HIV; dendritic cells; complement; innate immune response; TLR signaling; T cell activation; NK cells; inflammation; antiviral response; immune evasion;

   Sammanfattning : Dendritic cells are key players during HIV pathogenesis, and shape both the immediate immune response at the site of infection as well as directing the adaptive immune response against the virus. HIV has developed a plethora of immune evasion mechanisms that hijack dendritic cell functions, suppressing their ability to mount an accurate immune response and exploiting them for efficient viral transfer to target T cells. LÄS MER

4. 3. Viperin, a multifunctional radical SAM enzyme : biogenesis and antiviral mechanisms

   Författare :Arunkumar Upadhyay; Anna K. Överby; Niklas Arnberg; Richard Lundmark; Michael Beard; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Viperin (virus-inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) is an interferon-induced antiviral protein. It has three distinct functional domains: the N-terminal domain, the radical SAM (S-adenosylmethionine) domain for binding iron-sulphur cluster, and the C-terminus domain. LÄS MER

5. 4. Rift Valley fever : consequences of virus-host interactions

   Författare :Maria Baudin; Magnus Evander; Clas Ahlm; Göran Bucht; Tomas Bergström; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rift Valley fever; Rift Valley fever virus; viral haemorrhagic fever; miscarriage; entry; charge; carbohydrates; high-throughput screening; antiviral; cell-based assay; medicinsk virologi; Medical Virology;

   Sammanfattning : Rift Valley fever virus (RVFV) is a mosquito-borne virus which has the ability to infect a large variety of animals including humans in Africa and Arabian Peninsula. The abortion rate among these animals are close to 100%, and young animals develop severe disease which often are lethal. LÄS MER

7. 5. Hepatitis C virus kinetics during antiviral treatment

   Författare :Tony Carlsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Hepatitis C virus RNA; genotype; kinetics; interferon-alpha; ribavirin.;

   Sammanfattning : It is estimated that 170 million individuals have chronic hepatitis C virus (HCV) infection, whereof 20-30% will develop end stage liver disease within 20-30 years. Antiviral therapy can stop this deterioration and clear the infection in 40-80% of the patients depending on treatment and HCV genotype. LÄS MER