Sökning: "antiviral response phenotype"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden antiviral response phenotype.

  1. 1. Effects of Complement Opsonization of HIV on Dendritic Cells : and Implications for the Immune Response

    Författare :Rada Ellegård; Marie Larsson; Jorma Hinkula; Johan D Söderholm; William Paxton; Linköpings universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; HIV; dendritic cells; complement; innate immune response; TLR signaling; T cell activation; NK cells; inflammation; antiviral response; immune evasion;

    Sammanfattning : Dendritic cells are key players during HIV pathogenesis, and shape both the immediate immune response at the site of infection as well as directing the adaptive immune response against the virus. HIV has developed a plethora of immune evasion mechanisms that hijack dendritic cell functions, suppressing their ability to mount an accurate immune response and exploiting them for efficient viral transfer to target T cells. LÄS MER

  2. 2. HIV induced humoral immune response with specific relevance to IgA

    Författare :Pia Skott; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; HIV; secretory lgA; neutralizing antibodies; mucosal immunity;

    Sammanfattning : Human Immunodeficiency Virus (HIV) transmission occurs primarily after hetero- and homosexual contact and across mucosal surfaces. The immune response in mucosal tissues is typified by secretory immunoglobulin A (SIgA), which is the predominant lg class in human external secretions. LÄS MER

  3. 3. Human cytomegalovirus : Development of resistance to antiviral drugs and mechanisms of NK-cell evasion

    Författare :Mehrdad Mousavi-Jazi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Human cytomegalovirus (HCMV), a member of the herpesviridae, is ubiquitous and causes persistent infections mostly without any clinical symptoms. However, HCMV infection is a major cause of morbidity and mortality among immunocompromised patients, especially transplant recipients and patients with AIDS. LÄS MER

  4. 4. Characteristics of EBV-infected B cell lines and B-CLL clones which determine their interaction with lymphocytes

    Författare :Javier Federico Avila-Carino; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; EBV; Burkitt Iymphoma; CLL; MLC; antiviral response phenotype; cytokines.;

    Sammanfattning : CHARACTERISTICS OF EBV-INFECTED B CELL LINES AND B-CLL CLONES WHICH DETERMINE THEIR INTERACTION WITH T LYMPHOCYTES Javier Federico Avila-Cariho Doctoral dissertation from the Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden The results concerning T Iymphocyte mediated recognition of Epstein-Barr virus (EBV) carrying Burkitt Iymphoma (BL) cell lines and EBV-infected chronic Iymphocytic leukemia (CLL) B cells contribute to the understanding of the generally harmless host-EBV interaction and may be extrapolated to the fate of normal B cells after EBV infection. The phenotype of EBV negative BL lines resembles resting B cells. LÄS MER

  5. 5. Immune modulation in chronic HBV and HCV infection

    Författare :Catharina Hultgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; HBV; HBeAg; HCV; NS3; chronic infection; humoral cellular immune response; Th1 Th2 cells; proliferative response;

    Sammanfattning : Chronic viral hepatitis is a major health problem worldwide. The two major viral causes for chronic hepatitis are the hepatitis B (HBV) and C viruses (HCV). HBV is a DNA virus with a rather limited genetic variability whereas HCV is an RNA virus with a high genetic variability. LÄS MER