Sökning: "antiviral drugs"
Visar resultat 16 - 20 av 59 avhandlingar innehållade orden antiviral drugs.
16. In vivo and in vitro models for determination of antiviral activity and resistance
Sammanfattning : The AIDS epidemic has been the driving force for the discovery of substances that inhibit the replication of human immunodeficiency virus (HIV). Much interest has earlier focused on a single gene product central to the life cycle of HIV and to all other retroviruses: the reverse transcriptase (RT), the enzyme responsible for synthesis of DNA from viral RNA. LÄS MER
17. From bedside to bench and back : future options for antiretroviral drugs in non-B HIV-1 subtypes
Sammanfattning : HIV-1 drug resistance remains a burden in low- and middle-income countries (LMIC). Regardless of the advances in antiretroviral (ARV) therapy, there is an increase in the trend of acquired and pre-treatment drug resistance mutations (DRM) in LMIC affected by diverse HIV-1 subtypes. LÄS MER
18. Cell and organoid models to develop new antivirals and diagnostic methods for emerging viruses
Sammanfattning : The ongoing global pandemic of severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) is only the latest reminder of the urgent need for new antiviral strategies and diagnostic tools to improve preparedness for emergence of new pathogenic RNA-viruses. A key obstacle for the development of antivirals and diagnostic tools has been the lack of good models to study RNA viruses. LÄS MER
19. Bringing Structure to Drug Discovery
Sammanfattning : Drug discovery is aided by structural information. The type of structural information needed depends on the question at hand. The methods that can be used to determine the absolute configuration of a newly synthesised compound are different from those needed to study ligand binding. LÄS MER
20. Structural Studies of Proteins involved in Nucleotide Metabolism : Studies of a ribonucleotide reductase from A. aeolicus and NUDT15
Sammanfattning : This thesis is separated into two parts. The first part concerns ribonucleotide reductase from Aquifex aeolicus. A. aeolicus is a hyperthermophilic bacterium that thrives at extremely high temperatures of 80-95 °C. LÄS MER