Sökning: "antithrombin"

Visar resultat 16 - 20 av 29 avhandlingar innehållade ordet antithrombin.

  1. 16. Inflammation and Coagulation Activity in Unstable Coronary Artery Disease and the Influences of Thrombin Inhibition

    Författare :Jonas Oldgren; Steen Husted; Uppsala universitet; []
    Nyckelord :Medical sciences; Unstable coronary artery disease; inflammation; coagulation; thrombin inhibition; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; kardiologi; Cardiology;

    Sammanfattning : In patients with unstable coronary artery disease, this study evaluated the degree of inflammation and coagulation activity, relations to myocardial cell damage, prognosis, and influences of randomisation to 72 h infusion with three different doses of inogatran, a direct thrombin inhibitor (n=904), or unfractionated heparin (n=305). Anticoagulant treatment effects were evaluated with aPT time. LÄS MER

  3. 17. The effect of sex hormones on hemostasis and cardiovascular riskfactors in postmenopausal women

    Författare :Ulla Pripp; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Postmenopausal women; cardiovascular risk factors; hemostasis; ambulatory blood pressure; angina pectoris; HRT;

    Sammanfattning : The influence of cardiac riskfactors and sex hormones on hemostasis were studied in healthy women (n=260) in Study I. Body mass Index (BMI), dyslipidemia, surgical menopause, smoking and years since menopause were associated with an increase of 28% in fibrinogen levels. BMI, total cholesterol (tot. chol. LÄS MER

  4. 18. Intestinal Ischemia and Reperfusion Injury - Pathophysiology as basis for novel treatment

    Författare :Zhengwu Sun; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; organ dysfunction; epithelium; endothelium; adhesion molecules; cytokines; protease inhibitor; Intestine; barrier; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Sammanfattning : Intestinal ischemia and reperfusion (I/R) is not infrequent in the clinical situation and the intestinal barrier plays an important role in gut barrier function, preventing not at least septic complications and potentially the development of the multiple organ dysfunction syndrome. Mechanisms of intestinal I/R induced gut epithelial and endothelial barrier dysfunction and remote organ dysfunction, as well as potential preventive and therapeutic modes of management were evaluated in the rat. LÄS MER

  5. 19. Coagulation, fibrinolysis and inflammation in open surgery for infrarenal abdominal aortic aneurysm

    Författare :Anders Holmberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Abdominal aortic aneurysm; blood coagulation; fibrinolysis; cytokines; leucocytes; flow cytometry; chemotaxis; lactoferrin; myeloperoxidase; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Elective repair of infrarenal abdominal aortic aneurysm (AAA) carries a mortality of 4-8% and there is a substantial incidence of serious non-lethal complications. During surgery there is a situation of relative ischaemia and subsequent reperfusion of the lower part of the body. LÄS MER

  7. 20. Novel chemical and enzymatic routes to the generation of heparin- related polysaccarides

    Författare :Jianhui Rong; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; heparin; heparan sulphate; biosynthesis; 2-O-sulphotransferase; neo-glycosaminoglycan; conjugation; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : Heparin and heparan sulphate (HS) are structurally related polysaccharides influencing various biological processes. The biological functions of heparin/HS largely depend on interactions between the negatively charged polysaccharide chains and a variety of proteins. LÄS MER