Sökning: "antigenic drift"

Hittade 4 avhandlingar innehållade orden antigenic drift.

  1. 1. Influenza A Virus : Spatial analysis of influenza genome trafficking and the evolution of the neuraminidase protein

    Författare :Dan Dou; Robert Daniels; Martin Schwemmle; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Influenza A virus; IAV; neuraminidase; NA; IAV genome trafficking; viral entry; viral replication; co-infection; antigenic drift; antigenic shift; NA assembly; transmembrane domain; evolution; Biochemistry; biokemi;

    Sammanfattning : Influenza A viruses (IAVs) are a common infectious agent that seasonally circulates within the human population that causes mild to severe acute respiratory infections. The severity of the infection is often related to how the virus has evolved with respect to the pre-existing immunity in the population. LÄS MER

  3. 2. Influenza virus : protection and adaptation

    Författare :Camilla Maria Mittelholzer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Human influenza A virus; DNA vaccine; Neutralisation test; Antigen drift;

    Sammanfattning : Influenza is an acute respiratory disease caused by influenza type A and B viruses. Human influenza viruses may infect up to 15% of the total population during the seasonal epidemics, causing many cases of severe illness. Each year, approximately 350 million doses of influenza vaccine are produced for protection of those at risk of severe disease. LÄS MER

  4. 3. Variable viral genes as genetic immunogens

    Författare :Karl Ljungberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Influenza; hemagglutinin; HIV-1; gp160; DNA vaccine; genetic immunization; CpG; GM-CSF; pseudovirus.;

    Sammanfattning : Influenza and HIV-1 are two highly variable viruses that cause extensive morbidity and mortality in many countries. The most cost-effective medical intervention against influenza is vaccination but this has to be repeated annually because of the low antigenicity of the vaccine. LÄS MER

  5. 4. Viruses on the wing : evolution and dynamics of influenza A virus in the Mallard reservoir

    Författare :Michelle Wille; Jonas Waldenström; Timm Harder; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Co-infections; Ecology; Epidemiology; Evolution; Host-Parasite Interactions; Immunity; Influenza A Virus; Mallard; Phylogeny; Virology; Waterfowl; Wild Birds; Wildlife Disease; Zoonotisk ekologi; Zoonotic Ecology;

    Sammanfattning : This thesis explores the evolution of avian influenza A viruses (IAV), as well as host-pathogen interactions between these viruses and their main reservoir host, the Mallard (Anas platyrhynchos). IAV is a genetically diverse, multi-host virus and wild birds, particularly dabbling ducks, are the natural reservoir. LÄS MER