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Visar resultat 1 - 5 av 103 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Pro- and anticoagulant activities of factor V

    Författare :Elisabeth Thorelli; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; activated protein C; protein S; factor VIII; factor V; procoagulant; anticoagulant; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

    Sammanfattning : Coagulation factor V (FV) is activated by thrombin through proteolytic cleavage at Arg-709, Arg-1018 and Arg-1545. Upon thrombin activation, the active form of factor V (FVa) is formed. FVa functions as a cofactor to factor Xa in the conversion of prothrombin to thrombin during coagulation. LÄS MER

  3. 2. Recurrent stroke : risk factors, predictors and prognosis

    Författare :Johanna Pennlert; Marie Eriksson; Per-Gunnar Wiklund; Bo Carlberg; Hélène Pessah-Rasmussen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stroke; risk factors; atrial fibrillation; anticoagulant; antiplatelet; intracerebral hemorrhage; stroke recurrence; socioeconomic status; medicin; Medicine;

    Sammanfattning : Background Many risk factors for stroke are well characterized and might, at least to some extent, be similar for first-ever stroke and for recurrent stroke events. However, previous studies have shown heterogeneous results on predictors and rates of stroke recurrence. LÄS MER

  4. 3. Anticoagulant protein C--structural and functional studies

    Författare :Lei Shen; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzymology; Proteins; Klinisk kemi; Clinical chemistry; serpins; membrane binding; factor V; protein C; protein S; Proteiner; enzymologi;

    Sammanfattning : Anticoagulant protein C is a vitamin K-dependent factor circulating in plasma as a zymogen of a serine protease. It is converted to its active form (APC) by the thrombin-thrombomodulin complex on the surface of endothelial cells. APC inhibits the generation of thrombin by selective proteolytic inactivation procoagulant factors Va and VIIIa. LÄS MER

  5. 4. Anticoagulant and antiarrhythmic agents for atrial fibrillation

    Författare :Natalia Mochalina; Malmö Klinisk koagulationsmedicin; []
    Nyckelord :;

    Sammanfattning : Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. AF treatment involves management of precipitating factors, rate- and rhythm control and anticoagulation for prevention of stroke and systemic thromboembolism. LÄS MER

  7. 5. Determinants of adverse events during oral anticoagulant treatment

    Författare :Marcus Lind; Jan-Håkan Jansson; Lars Johansson; Kurt Boman; Sam Schulman; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oral anticoagulants; warfarin; mortality; bleeding; biomarkers; Medicine; medicin;

    Sammanfattning : Treament with oral anticoagulation is highly effective in reducing the burden of thromboembolic complications in several clinical conditions. The number of patients receiving oral anticoagulation is growing steadily. InSwedenabout 1.5 percent of the population receives treatment. LÄS MER