Sökning: "antibody"

Visar resultat 6 - 10 av 1323 avhandlingar innehållade ordet antibody.

1. 6. Antibody Development - Examples from viral and proteomic studies

   Författare :Fredrika Carlsson; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteome specific antibodies; cytomegalovirus; phage display; antibody characterization; antibody development; antibody repertoires;

   Sammanfattning : This thesis, which is based on four original papers, covers different aspects of antibody development. The overall goal of my work has been to obtain an increased understanding of antibody repertoires as they develop in vivo and in vitro. LÄS MER

3. 7. Antibody based plasma protein profiling

   Författare :Ulrika Qundos; Jochen M. Schwenk; Peter Nilsson; Mathias Uhlén; Ulrike Korf; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein profiling; plasma; antibody; affinity proteomics; biomark- ers; multiplex; assay development;

   Sammanfattning : This thesis is about protein profiling in serum and plasma using antibody suspension bead arrays for the analysis of biobanked samples and in the context of prostate cancer biomarker discovery. The influence of sample preparation methods on antibody based protein profiles were investigated (Papers I-III) and a prostate cancer candidate biomarker identified and verified (Papers III-V). LÄS MER

4. 8. Antibody Feedback Regulation and T Cells

   Författare :Fredrik Carlsson; Birgitta Heyman; Alf Grandien; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fc receptors; B cell; T cell; antigen presentation; complement receptors; complement; IgE; IgG3; CD23; antibody; Immunology; Immunologi;

   Sammanfattning : Antibodies, passively administered or actively produced, regulate immune responses to the antigen they recognize. This phenomenon is called antibody-mediated feedback regulation. Feedback regulation can be positive or negative, resulting in >1000-fold enhancement or >99% suppression of the specific antibody response. LÄS MER

5. 9. Antibody repertoires : Exploration of their role in allergic disease and facilitation of reliable analyses thereof

   Författare :Linnea Thörnqvist; Institutionen för immunteknologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; allergen; allergic disease; antibody bioinformatics; antibody repertoire; B cells; epitope; immunogloblulin; immunogloblulin germline gene; IgE; specific immunotherapy; stereotyped antibody;

   Sammanfattning : Allergic disease affects millions of individuals worldwide and leads to both impaired life quality of the affected individuals and large economic costs for the society. Allergen-specific antibodies of IgE type act as one of the key players in the disease, by activating effector cells upon binding of its allergen. LÄS MER

7. 10. Modeling Antibody Aggregation in Downstream Processing

   Författare :Frida Ojala; Avdelningen för kemiteknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Antibody; Aggregation; Downstream processing; Size exclusion chromatography; Reversible reaction model; General rate model;

   Sammanfattning : Antibodies are part of the immune system where their purpose is to recognize and neutralize foreign species such as viruses and bacteria, thus preventing and curing infections. The trend of using antibodies in the treatment of, for example, cancer is increasing. LÄS MER