Sökning: "antibody repertoires"
Visar resultat 11 - 15 av 18 avhandlingar innehållade orden antibody repertoires.
11. Genetic and functional analysis of the adaptive immune response
Sammanfattning : The cells of the adaptive immune system rely on somatic recombination of V, D and J genes to obtain a vast range of specificities. T cells use four chains encoded by three genomic loci, to produce alpha/beta or gamma/delta T cell receptors (TCRs). LÄS MER
12. B cell transcriptomics and immunoglobulin genetics in rheumatoid arthritis
Sammanfattning : Rheumatoid Arthritis (RA) is a complex autoimmune disease characterized by inflammation of the peripheral joints. The exact disease pathology remains to be elucidated, but it has been hypothesized that autoreactive B cells and autoantibodies play a major role in the etiology. LÄS MER
13. Characterization of Antigenic Properties and High Throughput Protein Purification
Sammanfattning : To understand the cellular processes, knowledge of the localization and function of proteins are essential. There are several high throughput ventures examining the human proteome. However, there are some bottlenecks in these ventures. For example the production and expression of soluble proteins for analysis. LÄS MER
14. Elicitation and enhancement of T and B cell responses
Sammanfattning : The Major histocompatibility complex class I (MHC-I) has been characterized in such great depth that a number of its key properties are well understood and part of its behavior can even be predicted. It is therefore intriguing that the impact of small epitope modifications on immunogenicity and the elicitation of T-cell repertoires remain often unpredictable and full of surprises. LÄS MER
15. Mechanisms influencing natural killer cell recognition of tumour cells
Sammanfattning : Natural killer (NK) cells are part of our innate immune defence against virus-infected and transformed cells. Through a yet undefined mechanism, expression of inhibitory receptors for self-HLA class I molecules endow NK cells with increased functionality. The process leading to gain of function through inhibition is known as NK cell education. LÄS MER