Sökning: "antibody repertoires"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden antibody repertoires.

  1. 1. Generation and evolution of human antibody repertoires

    Detta är en avhandling från Department of Immunotechnology, Lund University

    Författare :Helena Persson; Lund University.; Lunds universitet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; specificity; Immunology; serology; transplantation; Immunologi; serologi; Biotechnology; Bioteknik; phage display; IgE; hapten; grass pollen allergen; diversity; antibody repertoire; antibody library; antibody evolution; affinity maturation; allergy;

    Sammanfattning : This thesis, which is based on five original papers, covers different aspects of antibody specificity and diversity, with the overall goal to understand the makeup of antibody repertoires and their functionality as they occur in vivo or as they are developed in the laboratory. Besides their importance in the adaptive immune response, antibodies have emerged as an invaluable tool in applications ranging from basic research to disease diagnostics and therapy. LÄS MER

  2. 2. Antibody Development - Examples from viral and proteomic studies

    Detta är en avhandling från Department of Immunotechnology, Lund University

    Författare :Fredrika Carlsson; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteome specific antibodies; cytomegalovirus; phage display; antibody characterization; antibody development; antibody repertoires;

    Sammanfattning : This thesis, which is based on four original papers, covers different aspects of antibody development. The overall goal of my work has been to obtain an increased understanding of antibody repertoires as they develop in vivo and in vitro. LÄS MER

  3. 3. Antibody Evolution and Repertoire Development

    Detta är en avhandling från Johan Lantto, Dept. of Immunotechnology, P.O.Box 7031, S-220 07 Lund, Sweden

    Författare :Johan Lantto; Lund University.; Lunds universitet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; virus neutralization; trinucleotide repeat; insertion; immunoglobulin variable genes; human cytomegalovirus; glycoprotein B; deletion; antibody; antibody repertoire;

    Sammanfattning : Antibodies are key players of the immune system in higher vertebrates, which provide a defense against potentially lethal threats from the environment. Besides their importance in the immune defense, antibodies have a great potential as reagents in biological chemistry and diagnostics, and as therapeutic agents against both infectious diseases and cancer. LÄS MER

  4. 4. Human antibody repertoires in normal physiology and in autoimmune disease

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Immunology, Microbiology, Pathology and Infectious Diseases

    Författare :Iris F. van Dijk Härd; Karolinska Institutet.; Karolinska Institutet.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The immune system has to balance the need for a broad protection from infectious agents against the risk of developing autoimmune disease. The elements of the immune system should provide clues about conditions under which physiological autoreactivity may develop into autoaggressive immunity, if analyzed against the background of the immune system in healthy individuals. LÄS MER

  5. 5. Molecular mechanisms of antibody diversification in human B-cells

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Laboratory Medicine

    Författare :Andrea Björkman; Karolinska Institutet.; Karolinska Institutet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : B-cells undergo several somatic rearrangement/mutational processes during development to diversify their immunoglobulin (Ig) receptors. First, the antigen binding Ig variable (V) region is assembled through V(D)J recombination. LÄS MER