Sökning: "antibody repertoire"

Visar resultat 6 - 10 av 44 avhandlingar innehållade orden antibody repertoire.

  1. 6. Antibodies for better or worse or Antibody variability in an egg-laying mammal and a novel strategy in the treatment of allergies

    Författare :Jeannette Johansson; Kjell-Olov Grönvik; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Antibody; variability; platypus; allergy; vaccine; adjuvant; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molecular Immunology; molekylär immunologi;

    Sammanfattning : Antibodies are a central part of the immune defense system, and a large variability in their specificity is needed in order to be able to react against all possible foreign substances we may encounter during our lives. In this thesis, results are presented from investigations into how an egg-laying mammal, the Australian duck-billed platypus (Ornithorhynchus anatinus) creates antibody variability. LÄS MER

  3. 7. Role of collagen type II specific antibodies in arthritis

    Författare :Estelle Bajtner; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serologi; transplantation; serology; Immunology; tolerance; collagen type II; CIA; B cell epitope; antibody; arthritis; Immunologi;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory disease resulting in destruction of cartilage and bone. The role of the B cells in RA pathogenesis clearly involves autoantibodies. Collagen type II (CII)-specific antibodies have been identified in RA synovium and synovial fluid. LÄS MER

  4. 8. B cell repertoire development in normal physiology and autoimmune disease

    Författare :Åsa Andersson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cell repertoire; connectivity; natural antibodies; non-obese diabetic NOD ; Ig therapy; Vh7183 gene family;

    Sammanfattning : The B cell repertoire in the neonatal immune system (IS) is characterised by reactivity towards self-components, including other immunoglobulin (Ig) V-regions. These properties have been suggested to be a requirement for the development of a normal immune system. LÄS MER

  5. 9. Approaches to modulate vaccine-induced antibody responses

    Författare :Martina Soldemo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Most successful licensed vaccines mediate protection by inducing antibody responses capable of protecting the individual from infection or disease. Despite the availability of many effective vaccines, we lack knowledge about fundamental aspects of B cell immunity and how we respond to complex real-world protein antigens. LÄS MER

  7. 10. Targeted monoclonal antibody therapy in chronic lymphocytic leukemia

    Författare :Claes Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic lymphocytic leukemia (CLL) is still regarded as an incurable disease with a great need for developing new therapies and optimizing existing treatment options. The development of targeted therapy, i.e. therapy interfering with specific molecules needed for carcinogenesis and tumor growth, is rapidly evolving. LÄS MER