Sökning: "antibody repertoire"
Visar resultat 21 - 25 av 44 avhandlingar innehållade orden antibody repertoire.
21. Genetic and functional analysis of the adaptive immune response
Sammanfattning : The cells of the adaptive immune system rely on somatic recombination of V, D and J genes to obtain a vast range of specificities. T cells use four chains encoded by three genomic loci, to produce alpha/beta or gamma/delta T cell receptors (TCRs). LÄS MER
22. B cell responses against the HIV-1 envelope glycoproteins
Sammanfattning : The fine specificities of vaccine-elicited B cell responses against complex proteins are not well understood, including those directed against the HIV-1 envelope glycoproteins (Env). Env is the only surface-exposed viral protein and hence a major vaccine target, in particular the conserved determinants of Env. LÄS MER
23. The development of the human immune system during the first five years of life
Sammanfattning : Systems immunology is a scientific field combining high-throughput analytic technologies and integrative data analysis to study the immune system from a holistic perspective. As the immune system is a complex integrated network of cells and proteins interacting in order to produce higher-level emergent behavior, the more traditional approach to immunological research is not fully capable of adequately describing these interactions. LÄS MER
24. Heavy Metal Superantigen : Genetic Regulation of Lymphocyte Activation by HgC12
Sammanfattning : Injections of subtoxic doses of HgCl2 (mercuric chloride) cause a systemic autoimmune disease in genetically predisposed rats and mice. My work was designed to elucidate how HgCl2 induces lymphocyte activation and how the response to HgCl2 is regulated in susceptible and resistant strains. LÄS MER
25. Biochemical studies of carbohydrate blood group antigens - Carbohydrate phenotype in relation to cellular glycosyltranferases
Sammanfattning : The possibility to alter the cell surface carbohydrate expression by insertion or deletion of glycosyltransferase genes is a powerful technique to study the biological function of selected carbohydrate antigens. However, shifting the equilibrium between competing glycosyltransferases might lead to unexpected phenotypic effects, such as accumulation of other carbohydrate antigens and exposure of antigen structures that normally are cryptic or present in minute amounts on the cell surface. LÄS MER