Sökning: "antibody level"

Visar resultat 21 - 25 av 220 avhandlingar innehållade orden antibody level.

1. 21. Biomarker Discovery in Cancer using Affinity Proteomics - Studies of B-cell lymphomas and Breast Cancer

   Författare :Frida Pauly; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; affinity proteomics; antibody microarray; cancer; B-cell lymphoma; breast cancer; biomarker discovery;

   Sammanfattning : The continual increase in incidence of cancer has created an urgent need for improved methods for diagnosis, prognosis and/or treatment. In this context, the field of biomarker research has expanded immensely during the last few years. This thesis, based on four original papers, revolves around protein biomarker discovery in cancer. LÄS MER

3. 22. Human antibody repertoires in normal physiology and in autoimmune disease

   Författare :Iris F van Dijk Härd; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The immune system has to balance the need for a broad protection from infectious agents against the risk of developing autoimmune disease. The elements of the immune system should provide clues about conditions under which physiological autoreactivity may develop into autoaggressive immunity, if analyzed against the background of the immune system in healthy individuals. LÄS MER

4. 23. Virus mediated induction of antibody independent cytotoxicity (VDCC) and enhancement of antibody dependent cytotoxicity (ADCC) in human lymphocytes in vitro

   Författare :Abdul-Razzak Alsheikhly; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Addition in vitro of small amounts of paramyxoviruses (Mumps or Sendai) to lymphocytes from healthy human donors induces a strong and non-selective cytotoxicity against a variety of target cells (VDCC, virus dependent cellular cytotoxicity). VDCC-like reactions are believed to play a role in vivo in the defense against virus infection and/or the causation of the tissue lesions associated with virus disease. LÄS MER

5. 24. Dementia Proteomics

   Författare :Julia Remnestål; Peter Nilsson; Anna Månberg; Pieter Jelle Visser; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dementia; Proteomics; Alzheimer s disease; Frontotemporal dementia; Antibody array; Suspension bead array; Cerebrospinal fluid; Protein profiling; Biomarker discovery; Bioteknologi; Biotechnology;

   Sammanfattning : The term dementia encompass a number of conditions arising as a consequence of tissue degeneration in the brain. This degeneration is caused by molecular events occurring on a cellular level including inflammation, defective waste disposal and accumulation of insoluble proteins and peptides. LÄS MER

7. 25. High-throughput protein analysis using mass spectrometry-based methods

   Författare :Tove Boström; Sophia Hober; Thomas Laurell; Ole N. Jensen; KTH; []
   Nyckelord :Proteomics; mass spectrometry; affinity proteomics; immunoenrichment; immunoprecipitation; IMAC; screening; protein production; protein purification; ISET; quantification; SILAC; stable isotope standard; antibody validation; Bioteknologi; Biotechnology;

   Sammanfattning : In the field of proteomics, proteins are analyzed and quantified in high numbers. Protein analysis is of great importance and can for example generate information regarding protein function and involvement in disease. Different strategies for protein analysis and quan- tification have emerged, suitable for different applications. LÄS MER