Sökning: "antibody characterization"

Visar resultat 11 - 15 av 97 avhandlingar innehållade orden antibody characterization.

1. 11. Characterization of α-synuclein oligomers : Implications for Lewy Body Disorders

   Författare :Thomas Näsström; Martin Ingelsson; Joakim Bergström; Lars Lannfelt; Poul Henning Jensen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; Alpha-synuclein; Lewy bodies; Oligomers; Reactive aldehydes; monoclonal antibody; Medical Science; Medicinsk vetenskap;

   Sammanfattning : Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy are disorders featuring accumulation of Lewy bodies in brain. The main component of these large insoluble intracellular inclusions is the presynaptic protein alpha-synuclein (α-synuclein). LÄS MER

3. 12. Computational analyses of biological sequences -applications to antibody-based proteomics and gene family characterization

   Författare :Mats Lindskog; Mathias Uhlén; Fredrik Sterky; Andersson Björn; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; antigen; antibodies; antibody-based proteomics; biocomputing; bioinformatics; Bioinformatics; Bioinformatik;

   Sammanfattning : Following the completion of the human genome sequence, post-genomic efforts have shifted the focus towards the analysis of the encoded proteome. Several different systematic proteomics approaches have emerged, for instance, antibody-based proteomics initiatives, where antibodies are used to functionally explore the human proteome. LÄS MER

4. 13. Multimodal Interaction Chromatography for the Investigation and Separation of Proteins

   Författare :Kristian Kallberg; Tillämpad biokemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hydrophobic interaction chromatography; Multimodal chromatography; Glycosylation; Antibody; Hemoglobin; Protein purification.;

   Sammanfattning : Minor structural changes on the surface of proteins can have tremendous impact on their biological properties. When producing therapeutic proteins it is therefore important to verify that the generated protein is the desired one. LÄS MER

5. 14. Genetic and serologic characterization of a Swedish human hantavirus isolate

   Författare :Marie Lindkvist; Göran Bucht; Clas Alhm; Per Juto; Rainer Ulrich; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hantavirus; puumalavirus; diagnostics; HFRS; nucleocapsid protein; B-cell epitopes; epitope-mapping; protein interactions; glycosylation; antibody response; cross-reactivity; Virology; Virologi;

   Sammanfattning : Hantaviruses are found practically all over the world and cause hemorrhagic fevers in man. Each year about 150,000 people are hospitalized in these zoonotic infections which can be of two types: hemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS), depending on the infecting virus. LÄS MER

7. 15. Cell line and protein engineering tools for production and characterization of biologics

   Författare :Anna-Luisa Volk; Johan Rockberg; Mathias Uhlen; Dickson Alan; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Pharmaceutical proteins; precision medicine; antibody engineering; epitope mapping; cell line development; split-GFP; Bioteknologi; Biotechnology;

   Sammanfattning : Our increasing understanding of disease mechanisms coupled with technological advances has facilitated the generation of pharmaceutical proteins, which are able to address yet unmet medical needs. Diseases that were fatal in the past can now be treated with novel biological medications improving and prolonging life for many patients. LÄS MER