Sökning: "antibiotics promote"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden antibiotics promote.

  1. 1. Pharmacokinetic and Pharmacodynamic Modeling of Antibiotics and Bacterial Drug Resistance

    Författare :Ami Fazlin Syed Mohamed; Lena Friberg; Teresa Dalla Costa; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacokinetics; pharmacodynamics; modeling; antibiotics; resistance; combination; Gram-negative bacteria; gentamicin; colistin; meropenem; newborn infants; critically ill patients; Infectious Diseases; Infektionssjukdomar; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Exposure to antibiotics is an important factor influencing the development of bacterial resistance.  In an era where very few new antibiotics are being developed, a strategy for the development of optimal dosing regimen and combination treatment that reduces the rate of resistance development and overcome existing resistance is of utmost importance. LÄS MER

  3. 2. Monitoring anti-infectives and antibiotic resistance genes : with focus on analytical method development, effects of antibiotics and national perspectives

    Författare :Ghazanfar Ali Khan; Jerker Fick; Klaus Kümmerer; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; method development; on-line solid phase extraction liquid chromatography mass spectrometry SPE LC-MS MS ; antibiotics; anti-infectives; constructed wetlands CWs ; denatured gradient gel electrophoresis DGGE ; percentage removal efficiency PRE ; shannon index; antibiotic resistance genes ARGs ; real-time polymerase chain reaction RT-PCR ; drug formulation facilities DFF ; wastewater; epidemiology; pandemic; influenza; compliance;

    Sammanfattning : Antibiotics are biologically active and are globally used in humans and animal medicine for treatment and in sub-therapeutic amounts as growth promoters in animal husbandry, aquaculture and agriculture. After excretion, inappropriate disposal and discharge from drug production facilities they enter into water bodies either as intact drugs, metabolites or transformed products. LÄS MER

  4. 3. Pharmacoepidemiology of Antibiotics, Weak Opioids and Statins with Special Reference to Socioeconomic Aspects - an Ecological Approach

    Författare :Karin Henricson; Institutionen för hälsovetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Farmakologi; toxicology; pharmacy; pharmacognosy; Pharmacological sciences; statins; weak opioids; antibiotics; effectiveness; socioeconomic factors; Ecologic studies; drug utilisation; farmakognosi; farmaci; toxikologi; Social medicine; Socialmedicin; samhällsmedicin;

    Sammanfattning : The influence of socioeconomic factors on drug utilisation has been studied by pharmacoepidemiological analyses involving 1) drugs that are used to cure disease, such as antibiotics, 2) drugs that are used to alleviate symptoms, such as weak opioids, and 3) drugs that are used to prevent disease, such as statins. In a large Swedish city (Malmö), the utilisation of four major drug groups (ATC-groups A = alimentation, C = circulation, N = nervous system, and R = respiration) correlated positively with an unfavourable socioeconomic situation, most pronouncedly with group N and least so with group R. LÄS MER

  5. 4. Towards novel antibacterials : Synthesis and identification of natural product inspired inhibitors of Chlamydia trachomatis and development of chemical probes targeting virulence of Pseudomonas aeruginosa

    Författare :Michael Saleeb; Mikael Elofsson; Anna Linusson Jonsson; Andreas Kirschning; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibacterials; antibiotics; small molecules; natural products; benzofuran; dihydrobenzofuran; the type III secretion system; Pseudomonas aeruginosa; Chlamydia trachomatis; phenotypic screening; high-throughput screening; surface plasmon resonance; drug discovery; bacterial toxins; enzyme inhibitors; organisk kemi; Organic Chemistry;

    Sammanfattning : Antibiotic resistance has evolved significantly to become one of the serious threats to public health today. Yet, the pipeline of new antibiotics is drying up and is lagging behind the challenging needs. LÄS MER

  7. 5. Protecting food with poison : Exploring ecotoxicity of agrochemicals and pharmaceuticals

    Författare :Oskar Nyberg; Michael Tedengren; Peter Fantke; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; LCA; ecotoxicology; uncertainty; antibiotics; aquaculture; pesticides; Ecotoxicology; ekotoxikologi;

    Sammanfattning : Chemicals are being emitted into the environment through human activities, such as agriculture or animal husbandry. Emissions can either occur intentionally, as pesticide application of crops, or inadvertently, such as pharmaceutical residues in wastewater effluents. LÄS MER