Sökning: "antibiotic interventions"

Visar resultat 1 - 5 av 44 avhandlingar innehållade orden antibiotic interventions.

  1. 1. From Penicillin Binding Proteins to Community Interventions : Mathematical and Statistical Models Related to Antibiotic Resistance

    Författare :Patricia Geli Rolfhamre; Åke Svensson; Mikael Andersson; Dan I. Andersson; Karl Ekdahl; Bruce R. Levin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistance; mathematical modeling; pharmacokinetics; pharmacodynamics; penicillin binding protein; postantibiotic effect; reversibility; selection; community intervention; Mathematical statistics; Matematisk statistik; matematisk statistik; Mathematical Statistics;

    Sammanfattning : Antibiotic resistance has become a major public health concern and mathematical models are important analytical tools for the understanding, evaluation and prediction of the resistance problem and related control strategies.The risk of emerging antibiotic resistance and selection has rarely been a concern in the design of antibiotic drug dosing regimens. LÄS MER

  3. 2. Composing Policy Interventions for Antibiotic Development

    Författare :Christopher Okhravi; Steve McKeever; Francesco Ciabuschi; Enrico Baraldi; Jonathan Michie; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; evidence-based policy; simulation; antibiotics; ontology; composition; alignment; docking; contracts; REA; research and development; design science research; domain-specific language; Information Systems; Informationssystem;

    Sammanfattning : Antibiotic resistance is eroding the efficacy of the drugs we have and, unless future science dictates otherwise, bacteria will eventually become resistant to whatever new antibiotics we discover. We must therefore plan for a continuous stream of innovation. Unfortunately, pharmaceutical firms have left the scene to pursue more profitable areas. LÄS MER

  4. 3. Multidrug-Resistant Escherichia coli and Klebsiella pneumoniae : Treatment, Selection and International Spread

    Författare :Thomas Tängdén; Otto Cars; Anders Johansson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Escherichia coli; Klebsiella pneumoniae; extended-spectrum beta-lactamases; carbapenemases; metallo-beta-lactamases; synergy; antibiotic interventions;

    Sammanfattning : The prevalence of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases (ESBLs) and carbapenemases is increasing worldwide. Therapeutic options for infections with these bacteria are limited not only by the production of ESBLs and carbapenemases, which confer resistance to cephalosporins and carbapenems, but also by frequent co-resistance to other antibiotics. LÄS MER

  5. 4. The economics of a silent pandemic - A health economic analysis of antibiotic resistance in Sweden

    Författare :Sofie Larsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Health economics; Economic analysis; Antibiotic resistance; Cost-effectiveness analysis; Production loss; QALY;

    Sammanfattning : The overall aim of this thesis was to analyze the health economic consequences of antibiotic resistance in Sweden, and to assess the implications of methodological assumptions related to measuring health in health economic analysis. The thesis consists of four papers. LÄS MER

  7. 5. Lessons from diagnosis-prescribing and antibiotic resistance surveillance in Ujjain, India : the lull before the storm

    Författare :Ashish Pathak; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :antibiotic prescribing;

    Sammanfattning : Background: The evolution of antibiotic resistance is a global public health crisis building over decades. In this build-up antibiotic use has been the main driver for antibiotic resistance. LÄS MER