Sökning: "antiarrhythmic drugs"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden antiarrhythmic drugs.

  1. 1. Mechanism of Action of the Antiarrhythmic Agent AZD7009

    Författare :Frida Persson; Göteborgs universitet; []
    Nyckelord :atrial fibrillation; antiarrhythmic drug; IKr; IKur; Ito; IKs; IKACh; INa; ICaL; cardiac action potential; early afterdepolarisation;

    Sammanfattning : Atrial fibrillation (AF) is the most common tachyarrhythmia in the adult population and is a major cause of morbidity and mortality. AF can be terminated and sinus rhythm restored by prolonging the action potential duration (APD) and the refractory period. LÄS MER

  3. 2. Outcomes and safety of new techniques for pulmonary vein isolation in patients with paroxysmal and persistent atrial fibrillation : A study based on randomised trials and registries

    Författare :David Mörtsell; Carina Blomström-Lundqvist; Stefan Lönnerholm; Isabel Deisenhofer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; atrial fibrillation; antiarrhythmic drugs; ablation; cryoballoon; radiofrequency; pulmonary vein isolation; quality of life; arrhythmia monitoring; implantable cardiac monitor; atrial fibrillation burden; health economics; Cardiology; Kardiologi;

    Sammanfattning : Atrial fibrillation (AF) is a common disease with a high prevalence in the adult population. Treatment of AF encompasses antiarrhythmic drugs and catheter ablation to reduce symptoms. LÄS MER

  4. 3. Catheter ablation compared to antiarrhythmic drugs in patients with atrial fibrillation : A study focusing on arrhythmic burden and quality of life

    Författare :Victoria Svedung Wettervik; Carina Blomström-Lundqvist; Elena Sciaraffia; Mattias Duytschaever; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Patients with atrial fibrillation (AF) experience symptoms and have impaired health-related quality of life (HRQoL). Rhythm control therapy, including antiarrhythmic drugs (AAD) and catheter ablation for pulmonary vein isolation, aims to relieve symptoms and improve HRQoL. LÄS MER

  5. 4. Antiarrhythmic and arrhythmic effects of an Ikr-blocking class III agent. A clinical and electrocardiographic study of almokalant

    Författare :Birgitta Houltz; Göteborgs universitet; []
    Nyckelord :Almokalant; class III antiarrhythmic agent; potassium channel blocker; atrial fibrillation; sinus rhythm; conversion; electrocardiographic; QT interval prolongation; T wave morphology; prediction; torsades de pointes; proarrhythmia; QT dispersion; ventric;

    Sammanfattning : The interest in class III drugs has increased over the last decades as being potent antiarrhythmic agents in their mode of action by prolongation of repolarization and with no effect on conduction. Class I antiarrhythmic agents have proven effective in conversion of atrial fibrillation (AF), but may cause serious proarrhythmia. LÄS MER

  7. 5. Real-Time Monitoring of Healthcare Interventions in Routine Care : Effectiveness and Safety of Newly Introduced Medicines

    Författare :Thomas Cars; Johan Sundström; Björn Wettermark; Martin Neovius; Til Stürmer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Electronic Health Records; Comparative Effectiveness Research; Comparative Safety Research; Sequential drug monitoring; propensity score; real-world data; infliximab; TNF-inhibitors; dronedarone; amiodarone; flecainide; Farmakoepidemiologi; Pharmacoepidemiology;

    Sammanfattning : Before market authorization of new medicines, their efficacy and safety are evaluated using randomized controlled trials. While there is no doubt about the scientific value of randomized trials, they are usually conducted in selected populations with questionable generalizability to routine care. LÄS MER