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Visar resultat 1 - 5 av 23 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. On causes and regulation of anti-viral defence in asthma and COPD

    Författare :Mandy Menzel; Respiratorisk immunofarmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; asthma; chronic obstructive pulmonary disease; rhinovirus; exacerbation; airway epithelial cell; ; pattern recognition receptors; interferon; allergen; azithromycin; inflammasome; epithelial-derived cytokines; oxidative stress; asthma; chronic obstructive pulmonary disease; rhinovirus; exacerbation; airway epithelial cell; pattern recognition receptors; interferon; allergen; azithromycin; inflammasome; epithelial-derived cytokines; oxidative stress;

    Sammanfattning : Rhinovirus infection is a main trigger of asthma and COPD exacerbations. dsRNA, a viral replication intermediate, is sensed by pattern recognition receptors in the airway epithelium leading to down-stream induction of anti-viral interferons. LÄS MER

  3. 2. Studies of specific immunity against viral infections in patients after stem cell transplantation

    Författare :Gayane Avetisyan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Stem cell transplantation; cytomegalovirus; influenza; cellular and humoral immunity; immunological monitoring; anti-viral treatment; vaccination;

    Sammanfattning : Recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT) experience a prolonged period of immune deficiency, resulting in significant morbidity and mortality from the infections. Viruses such as cytomegalovirus (CMV) and influenza virus are frequent causes of infectious complications following allo-HSCT. LÄS MER

  4. 3. Hepatitis C in chronic kidney disease and kidney transplantation : with special reference to epidemiology and treatment

    Författare :Annette Bruchfeld; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hepatitis C; kidney transplantation; patient and graft survival; renal replacement therapy; dialysis; renal insufficiency; interferon-alpha; ribavirin; plasma concentration; anaemia; population pharmacokinetics; renal function.;

    Sammanfattning : Hepatitis C (HCV) is a clinical problem in infected kidney transplant patients but is also a cause of renal disease and vasculitis. Standard therapy for HCV is a combination of interferon and ribavirin. LÄS MER

  5. 4. Interaction Characteristics of Viral Protease Targets and Inhibitors : Perspectives for drug discovery and development of model systems

    Författare :Cynthia F Shuman; Jordan J N Tang; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; viral proteases; biomolecular interactions; kinetics; thermodynamics; biosensors; drug discovery; Biokemi; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Sammanfattning : Viral proteases are important targets for anti-viral drugs. Discovery of protease inhibitors as anti-viral drugs is aided by an understanding of the interactions between viral protease and inhibitors. This thesis addresses the characterization of protease-inhibitor interactions for application to drug discovery and model system development. LÄS MER

  7. 5. The clinical perspective on malignancies in renal transplanted patients

    Författare :Vivan Hellström; Tomas Lorant; Gunnar Tufveson; Gunilla Enblad; Per Lindnér; Uppsala universitet; []
    Nyckelord :renal transplantation; malignant tumours;

    Sammanfattning : Post-transplant malignancies cause significant morbidity and mortality. In this thesis we investigated malignancies in renal transplanted patients from a clinical viewpoint. The use of regional tumour registries considerably improved identification of pre- and post-transplant malignancies, which are generally underreported in transplant registries. LÄS MER