Sökning: "anti-phospholipid antibodies"

Hittade 4 avhandlingar innehållade orden anti-phospholipid antibodies.

  1. 1. Autoimmunity in Africa: Comparing Systemic Lupus Erythematosus and Anti-phospholipid Antibodies in Sudan and Sweden

    Författare :Sahwa Elbagir; Johan Rönnelid; Iva Gunnarsson; Amir I Elshafie; Bo Nilsson; Cem Gabay; Uppsala universitet; []
    Nyckelord :SLE; anti-phospholipid antibodies; IgA; immune complexes; pregnancy; autoimmunity; Sudan; Africa; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : Systemic Lupus Erythematosus (SLE) is a chronic immune complex (IC)-mediated disease with variable prevalence worldwide, reported to be more common in Africans, Hispanics and Asians than in Caucasian populations. Expression of autoantibodies might vary between different ethnic populations due to environmental and genetic factors. LÄS MER

  3. 2. Genetic Analyses of Multiple Sclerosis and Systemic Lupus Erythematosus : From Single Markers to Genome-Wide Data

    Författare :Johanna K Sandling; Ann-Christine Syvänen; Lovisa Lovmar; Joseph Terwilliger; Javier Martín Ibáñez; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic lupus erythematosus; Multiple Sclerosis; Association study; Type I interferon system; Single nucleotide polymorphism; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Molekylär medicin; Molecular Medicine;

    Sammanfattning : In autoimmune diseases an individual’s immune system becomes targeted at the body’s own healthy cells. The aim of this thesis was to identify genetic risk factors for the two autoimmune diseases multiple sclerosis (MS) and systemic lupus erythematosus (SLE). LÄS MER

  4. 3. Studies on hereditary C2 deficiency: Frequent occurrence of severe infections, atherosclerosis and rheumatological manifestations

    Författare :Göran Jönsson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; serology; Immunology; mykologi; bakteriologi; virologi; Mikrobiologi; mycology; Complement; Complement C2 deficiency; Infectious diseases; Atherosclerosis; SLE; Autoantibodies; GM allotypes; Immunodeficiency state; Medicine human and vertebrates ; Medicin människa och djur ; Microbiology; virology; bacteriology; Immunologi; serologi; Infections; Infektioner;

    Sammanfattning : The complement system is a part of the innate immunity and is essential in the defence against microorganisms. Hereditary C2 deficiency (C2D) is one of the most common complement deficiency states with an estimated prevalence of 1:20,000 in persons of Western descent. LÄS MER

  5. 4. Cardiovascular Disease and Immune Mechanisms in Systemic Lupus Erythematosus

    Författare :Dag Leonard; Lars Rönnblom; Gunnel Nordmark; Maija-Leena Eloranta; Søren Jacobsen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic Lupus Erythematosus; Cardiovascular Disease; Intima-Media Thickness; STAT4; IRF8; Interferon-α; Plasmacytoid dendritic cell; GM-CSF; IL-3; Medicin; Medicine; Genetics; Genetik; Immunologi; Immunology;

    Sammanfattning : Systemic lupus erythematosus (SLE) is an autoimmune, inflammatory disease characterized by autoantibody production and an activated type I interferon system. Cardiovascular disease (CVD) is as a major cause of morbidity and mortality. The aim of this thesis was to identify genetic risk factors for CVD in SLE. LÄS MER