Sökning: "anti-angiogenic therapy"

Visar resultat 1 - 5 av 27 avhandlingar innehållade orden anti-angiogenic therapy.

1. 1. MOLECULAR ASPECTS OF ENDOTHELIAL CELL FUNCTION AND HYPOXIA-DEPENDENT TUMOR ANGIOGENESIS

   Författare :Paulina Kucharzewska; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypoxia; hypoxia-inducible factor; angiogenesis; anti-angiogenic therapy; endothelial cell; polyamines; microRNA; extracellular membrane vesicles; exosomes; glioblastoma;

   Sammanfattning : Hypoxia, or deficient oxygen levels, is an inherent feature of rapidly expanding tumor tissue. In order to survive in the hostile, hypoxic environment and to restore the supply of oxygen and nutrients tumor cells activate a variety of adaptive mechanisms. Among them, hypoxia-induced angiogenesis, i.e. LÄS MER

3. 2. On the Role of Polyamines and Microvesicles in Tumour Development. Regulation by Hypoxia and Implications for Therapeutic Intervention of Cancer

   Författare :Johanna Welch; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heparan sulphate proteoglycans; cancer; hypoxia; polyamines; microvesicles; anti-angiogenic therapy; angiogenesis;

   Sammanfattning : Novel strategies for specific tumour cell targeting are necessary in order to improve survival rates and to reduce side effects of current therapies in cancer patients. Hypoxia is a hallmark of solid tumours and one of the major driving forces for tumour progression. LÄS MER

4. 3. Identifying molecular targets for cancer therapy

   Författare :W David Culp; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Within cancer research a molecular target is a specific molecular attribute in a cancer cell or tumor tissue that may play a role in promoting disease progression. There are many of these molecular attributes present in cancer biology and they represent events for therapeutic intervention. LÄS MER

5. 4. Novel experimental targeted therapy of neuroblastoma

   Författare :Lova Perup Segerström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Neuroblastoma, a malignancy of the sympathetic nervous system, is the most common solid extracranial tumor of infancy and is responsible for around 15% of the cancer-related deaths in children. For the entire group the survival has increased over the last decades, but despite today's intense muti-modal therapy the survival of high-risk neuroblastomas lies just around 50%. LÄS MER

7. 5. Myocardial gene therapy and gene expression in angina pectoris

   Författare :Andreas Rück; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Angina pectoris; gene therapy; vascular endothelial growth factor; plasmid; prognosis; collaterals; angiogenesis; gene expression; microarray; natriuretic peptides.;

   Sammanfattning : Background: Angiogenesis does not fully counteract myocardial ischemia in stable angina pectoris. Refractory angina pectoris, with remaining symptoms despite medication and no possibility for bypass surgery or angioplasty, is rather common. Angiogenic gene therapy is a novel treatment strategy for these patients. LÄS MER