Sökning: "anti-HIV"

Visar resultat 1 - 5 av 40 avhandlingar innehållade ordet anti-HIV.

1. 1. Towards a New Generation of Anti-HIV Drugs : Interaction Kinetic Analysis of Enzyme Inhibitors Using SPR-biosensors

   Författare :Malin Elinder; U. Helena Danielson; Maurizio Botta; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug discovery; fragment; screening; reverse transcriptase; microbicides; interaction analysis; NNRTIs; Biochemistry; Biokemi; Biokemi; Biochemistry;

   Sammanfattning : As of today, there are 25 drugs approved for the treatment of HIV and AIDS. Nevertheless, HIV continues to infect and kill millions of people every year. Despite intensive research efforts, both a vaccine and a cure remain elusive and the long term efficacy of existing drugs is limited by the development of resistant HIV strains. LÄS MER

3. 2. Dynamic Chemistry for Asymmetric Synthesis, Molecular Motion and Constitutional Exchange

   Författare :Yansong REN; Licheng Sun; Olof Ramström; Anna Hirsch; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; dynamic chemistry; constitutional dynamic chemistry; motional dynamics; dynamic kinetic resolution; enzyme; subtilisin Carlsberg; Candida antarctica lipase B; anti-HIV; 1; 3-oxathiolane; dynamic exchange; enamines; E Z-isomerization; molecular switches; aggregation; gelation; fluorescence.; dynamisk kemi; konstitutionell dynamisk kemi; molekylär rörelsedynamik; dynamisk kinetisk resolvering; enzym; subtilisin Carlsberg; Candida antarctica lipase B; anti-HIV; 1; 3-oxatiolan; dynamisk utbyte; enaminer; E Z-isomerisering; molekylära omkopplare; aggregering; gelbildning; fluorescens.; Kemi; Chemistry;

   Sammanfattning : Living matter is built on complex dynamic systems consisting of numerus biotransformations. By exploiting the adaptive and evolutive behaviors ofmolecular matter, dynamic chemistry has developed as an important tool tounderstand the organization of nonliving matter into complex living systems. LÄS MER

4. 3. Beta-chemokine and CD8+ T-cell noncytotoxic anti-HIV/SIV activity

   Författare :Raija Ahmed; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : A small number of individuals remain uninfected despite repeated exposure to HIV. A number of viral and host factors are thought to account for this resistance. The cell-mediated immune response is likely to be important in controlling HIV/SIV infections. LÄS MER

5. 4. Expression of recombinant neutralizing anti-HIV-1 antibodies in bacteria and eukaryotic cells

   Författare :Fayezeh Yari; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Phage display; vector; monoclonal antibody; antigen; eukaryotic; prokaryotic; transfection; selection; transient expression; stable cell line; neutralizing antibody; expression; HIVA-1; gp41; gp120;

   Sammanfattning : The main purpose of this study was to investigate and optimize techniques for eukaryotic expression of antibody molecules (IgG, Fab and scFV-ê formats), derived from an immune phage displayed Fab library and reactive against HIV-1 glycoproteins gp120 and gp41. Light and heavy-chain (Fd) DNA from a number of Fab clones were transferred from a prokaryotic phagemid vectors to mammalian expression vectors. LÄS MER

7. 5. Studies on the efficacy of potent anti-HIV-1 therapy on virological and immunological factors

   Författare :Soo Aleman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The aim of this thesis was to assess to which extent treated human immunodeficiency virus type I (HIV-1) infected patients with a seemingly controlled, defined as undetectable plasma HIV-1 RNA levels (< 50 copies/ml), or low-grade viral replication, exhibited pattems in virological and immunological factors which could suggest a continuation of the disease process. We have therefore analysed the kinetics of HIV-1 DNA levels (Papers I and II), the viral evolution (Paper II), the changes in Beta-chemokine levels (Paper 111) and sCD27 levels (Paper IV), and the appearance of drug resistance associated mutations (Paper V) in such patients. LÄS MER