Sökning: "anna skogh"

Hittade 2 avhandlingar innehållade orden anna skogh.

  1. 1. Development of Substance P 1–7 Related Peptides and Peptidomimetics : Targeting Neuropathic Pain

    Författare :Anna Skogh; Anja Sandström; Christian Sköld; Rebecca Fransson; Philip Thompson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Substance P 1–7; Peptidomimetics; Solid-phase Peptide Synthesis SPPS ; Palladium catalysis; Carbonylation; Imidazole; Bioisostere; Neuropathic pain; Allodynia; Structure-activity relationships; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : The neuropeptide substance P 1–7 (SP1–7, H-Arg1-Pro2-Lys3-Pro4-Gln5-Gln6-Phe7-OH) and its amidated analogue SP1–7 amide, have displayed intriguing effects in experimental models for neuropathic pain acting on a specific, yet unknown SP1–7 target. The aim of this thesis was to design and synthesise SP1–7 related peptides and peptidomimetics, to be used as research tools to study the SP1–7 system, and to serve as drug leads in the neuropathic pain area. LÄS MER

  3. 2. Circulating and Mucosal Antibodies to Citrullinated Antigens in Rheumatoid Arthritis

    Författare :Anna Svärd; Thomas Skogh; Alf Kastbom; Carl Turesson; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation and subsequent destruction of cartilage and bone. The etiology is largely unknown, although genetic as well as environmental factors are involved. The manifestations and consequences of RA differ between individuals. LÄS MER