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1. Human papillomavirus testing and its application in cervical cancer prevention
Sammanfattning : SUMMARY Because of the strong causal relationship between persistent infections of human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) and cancer, HPVtesting has been proposed for improvement of cervical screening programs, including triaging and follow-up after treatment for CIN. We developed two new methods for HPV-testing with genotyping: A high-throughput HPV genotyping method that uses mass spectrometry for detection of the products of type-specific mass extend reactions, and a method with particularly sensitive detection of a broad spectrum of HPV-types, also in the case of multiple infections, that uses type-specific probes coupled to fluorescent beads for detection on the Luminex platform. LÄS MER
