Sökning: "angiotensin"

Visar resultat 21 - 25 av 193 avhandlingar innehållade ordet angiotensin.

  1. 21. Calcium Responses in the Renal Afferent Arteriole to Angiotensin II and Norepinephrine Stimulation

    Författare :Mark Kornfeld; Klinisk neurofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; norepinephrine; angiotensin II; smooth muscle cells; afferent arteriole; calcium; Kidney; renal hemodynamics; Physiology; Fysiologi;

    Sammanfattning : Studies were performed to investigate the influence of the vasoconstrictors angiotensin II (AII) and norepinephrine (NE) on calcium metabolism in smooth muscle cells of afferent arterioles. Fura-2 and image analysis techniques were used to evaluate calcium responses in the proximal and distal parts of afferent arterioles with attached glomeruli. LÄS MER

  3. 22. Design and Synthesis of Angiotensin IV Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP)

    Författare :Hanna Andersson; Anders Hallberg; Anders Karlén; Federico Corelli; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiotensin IV; AT4; insulin-regulated aminopeptidase IRAP ; inhibitor; peptidomimetics; γ-turn mimetic; macrocycle; Pharmaceutical chemistry; Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : Peptidomimetics derived from the bioactive hexapeptide angiotensin IV (Ang IV, Val1-Tyr2-Ile3-His4-Pro5-Phe6) have been designed and synthesized. These peptidomimetics are aimed at inhibiting the insulin-regulated amino peptidase (IRAP), also known as the AT4 receptor. LÄS MER

  4. 23. Helicobacter pylori associated effects on inflammatory radical formation and angiotensin II receptors in the stomach

    Författare :Anders Elfvin; Göteborgs universitet; []
    Nyckelord :Helicobacter pylori; Mongolian gerbil; gastric adenocarcinoma; nitro-radical; iNOS; nitric oxide; nitrotyrosine; oxy-radical; myeloperoxidase; angiotensin II; AT1R; AT2R;

    Sammanfattning : Helicobacter pylori infection of the stomach always results in mucosal inflammation and a marked systemic immune response. Despite the profound host defence reactions the bacterium avoids elimination and persists in the mucosa. This results in chronic inflammation and an increased risk for peptic ulcers and adenocarcinoma. LÄS MER

  5. 24. Ligands of the Angiotensin II Type 2 Receptor : Exploring structure and function of the AT2R ligand C38

    Författare :Rebecka Isaksson; Mats Larhed; Annette Bayer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiotensin II type 2 receptor; AT2R antagonists; sulfonyl carbamates; bicyclic amides; metabolic stability; functional activity assay; pharmacological profile; medicinal chemistry; structure-activity relationship; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : The renin-angiotensin-aldosterone-system (RAAS) control blood-pressure regulation, exerted by the main effector peptide angiotensin II (AngII) binding the angiotensin II type 1 receptor (AT1R). While hypertension is the most known disease caused by over-activity in RAAS, several proteins in the system exhibit protective functions. LÄS MER

  7. 25. Renal hemodynamics in renal artery stenosis and angiotensin II-dependent hypertension. Pathophysiological and diagnostic aspects

    Författare :Aso Saeed; Göteborgs universitet; []
    Nyckelord :angiotensin II; autoregulation of renal blood flow; color duplex sonography; endothelin-1; oxidative stress; renal artery stenosis; renal hemodynamics; renovascular hypertension;

    Sammanfattning : Patients with renovascular hypertension have a poor renal and cardiovascular prognosis. To improve the care of these patients, we need to increase knowledge about the pathophysiological mechanisms involved. LÄS MER