Avancerad sökning

Visar resultat 1 - 5 av 193 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. On angiotensin II receptor type 2 receptors in the small intestine

    Författare :Sara Ewert; Göteborgs universitet; []
    Nyckelord :renin-angiotensin; angiotensin; small intestine; mucosa; epithelium; AT1; AT2; bradykinin; BK2 receptor; nitric oxide; iNOS; smooth muscle; contractility;

    Sammanfattning : The endocrine renin-angiotensin system (RAS) is important in the regulation of extracellular fluid volume and systemic blood pressure in strenuous conditions such as hypovolemia. Also present locally in peripheral tissues, all components of RAS are expressed and have been shown to modulate development, cell growth and inflammation. LÄS MER

  3. 2. Synthesis of Aldehyde-Functionalized Building Blocks and Their Use for the Cyclization of Peptides : Applications to Angiotensin II

    Författare :Petra Johannesson; Rob M. J. Liskamp; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Synthesis; Aldehyde; Cyclization; Peptide; Angiotensin II; Ang II; Bioactive Conformation; Solid Phase Peptide Synthesis; Dimethyl Acetal; Farmaceutisk kemi; Syntes; Aldehyd; Cyklisering; Peptid; Bioaktiv konformation; Fast-fas peptidsyntes; Dimetylacetal; Pharmaceutical chemistry; Farmaceutisk kemi; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

    Sammanfattning : This study addresses the issue of how to convert peptides into drug-like non- peptides with retained biological activities at peptide receptors. Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, Ang II) was used as a model peptide. LÄS MER

  4. 3. Angiotensin-Converting Enzyme : Effects of Smoking and Other Risk Factors for Cardiovascular Diseases

    Författare :Liza Ljungberg; Karin Persson; Rolf Andersson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Cardiovascular diseases (CVDs) are the most common cause of death in Western countries. Smoking, hypertension, diabetes mellitus and hypercholesterolemia are considered as major risk factors. However, the underlying mechanisms by which these factors cause CVDs are not entirely clear. LÄS MER

  5. 4. On the possible role of serotonin and angiotensin for the respiratory abnormalities observed in panic disorder and premenstrual dysphoria

    Författare :Marie Olsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; panic disorder; premenstrual dysphoria; serotonin; paroxetine; PCPA; angiotensin; saralasin; respiration; respiratory variability; CO2; sodium lactate; female sex steroids; estrus cycle; Wistar rats;

    Sammanfattning : Panic disorder and premenstrual dysphoria are accompanied by intriguing abnormalities related to the control of respiration, including enhanced responsiveness to CO2 and enhanced respiratory variability. These aberrations do not seem to be shared by other psychiatric disorders, but appear to be relatively unique for panic disorder and premenstrual dysphoria. LÄS MER

  7. 5. The renin-angiotensin system in renal tubulogenesis. Experimental studies in the rat

    Författare :Daina Lasaitiene; Göteborgs universitet; []
    Nyckelord :angiotensin II; extracellular matrix; inflammation; mitochondrial biogenesis; renal development; renin-angiotensin system; thick ascending limb of Henle; tubulogenesis;

    Sammanfattning : The kidney and the renin-angiotensin system (RAS) are vital regulators of blood pressure and salt-water balance. In order to appropriately regulate circulatory homeostasis, the kidney must undergo normal development, in which the RAS plays a crucial role. LÄS MER