Sökning: "angiotensin II"

Visar resultat 16 - 20 av 152 avhandlingar innehållade orden angiotensin II.

  1. 16. Renal hemodynamics in renal artery stenosis and angiotensin II-dependent hypertension. Pathophysiological and diagnostic aspects

    Författare :Aso Saeed; Göteborgs universitet; []
    Nyckelord :angiotensin II; autoregulation of renal blood flow; color duplex sonography; endothelin-1; oxidative stress; renal artery stenosis; renal hemodynamics; renovascular hypertension;

    Sammanfattning : Patients with renovascular hypertension have a poor renal and cardiovascular prognosis. To improve the care of these patients, we need to increase knowledge about the pathophysiological mechanisms involved. LÄS MER

  3. 17. Helicobacter pylori associated effects on inflammatory radical formation and angiotensin II receptors in the stomach

    Författare :Anders Elfvin; Göteborgs universitet; []
    Nyckelord :Helicobacter pylori; Mongolian gerbil; gastric adenocarcinoma; nitro-radical; iNOS; nitric oxide; nitrotyrosine; oxy-radical; myeloperoxidase; angiotensin II; AT1R; AT2R;

    Sammanfattning : Helicobacter pylori infection of the stomach always results in mucosal inflammation and a marked systemic immune response. Despite the profound host defence reactions the bacterium avoids elimination and persists in the mucosa. This results in chronic inflammation and an increased risk for peptic ulcers and adenocarcinoma. LÄS MER

  4. 18. Ligands of the Angiotensin II Type 2 Receptor : Exploring structure and function of the AT2R ligand C38

    Författare :Rebecka Isaksson; Mats Larhed; Annette Bayer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiotensin II type 2 receptor; AT2R antagonists; sulfonyl carbamates; bicyclic amides; metabolic stability; functional activity assay; pharmacological profile; medicinal chemistry; structure-activity relationship; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : The renin-angiotensin-aldosterone-system (RAAS) control blood-pressure regulation, exerted by the main effector peptide angiotensin II (AngII) binding the angiotensin II type 1 receptor (AT1R). While hypertension is the most known disease caused by over-activity in RAAS, several proteins in the system exhibit protective functions. LÄS MER

  5. 19. Palladium(0)-Catalyzed Spirocyclization and Carbonylation Reactions : Ligands Targeting the Angiotensin II Type 2 Receptor

    Författare :Jens Lindman; Mats Larhed; Johan Gising; Christian Sköld; Alessandra Tolomelli; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Palladium catalysis; Mizoroki-Heck reaction; spiroindolines; spirooxindoles; amino acids; carbonylation; angiotensin II type 2 receptor; AT2R ligands; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : Palladium(0)-catalyzed chemistry represents one of the most important methods for the construction of carbon-carbon bonds, which are ubiquitous in organic compounds. The first part of this thesis describes the palladium(0)-catalyzed diastereoselective Mizoroki-Heck reaction of Vince lactam-derived precursors for the formation of spiroindolines (paper I) and spirooxindoles, which are scaffolds present in several natural products with interesting biological activity. LÄS MER

  7. 20. Design and Synthesis of AT2 Receptor Selective Angiotensin II Analogues Encompassing β- and γ-Turn Mimetics

    Författare :Ulrika Rosenström; Anders Hallberg; Stephen Hanessian; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Angiotensin II; AT2; AT1; Benzodiazepine; Peptidomimetics; γ-turn; β-turn; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : Important information on the bioactive conformation of biologically active peptides may be obtained by studies of rigid peptides or well-defined secondary structure mimetics incorporated into pseudopeptides. The structural requirements for the interaction of angiotensin II (Ang II, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) with its AT1 and AT2 receptors were the subject of this study. LÄS MER