Sökning: "angiopoietin and receptor"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden angiopoietin and receptor.

  1. 1. Examining the prostate stroma and vasculature : importance and potential as targets for therapy

    Författare :Anna Johansson; Anders Bergh; Arne Östman; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; castration therapy; vasculature; stroma; the angiopoietins; the PDGF-receptors; mast cells; Pathology; Patologi;

    Sammanfattning : Background. Recent studies in cancer research have focused on the reciprocal interaction between cancer cells and their microenvironment. Tumour growth is angiogenesis dependent and the rate of angiogenesis correlates with a poor prognosis in many different cancers. LÄS MER

  3. 2. Angiopoietin-like protein 4 : an unfolding chaperone regulating lipoprotein lipase activity

    Författare :Valentina Sukonina; Gunilla Olivecrona; Lena Kjellen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipoprotein lipase; angiopoietin-like protein 4; protein folding; human adipose tissue; macrophages; peroxisome proliferator-activated receptor delta PPARδ ; Medical microbiology; Medicinsk mikrobiologi;

    Sammanfattning : Lipoprotein lipase (LPL) is the main enzyme hydrolyzing triglyceride-rich lipoproteins in plasma. Proteoglycan-bound LPL on the vascular endothelium represent the functional pool of active enzyme. LPL is regulated in a tissue specific manner according to metabolic demands. LÄS MER

  4. 3. On the role of gut microbiota in intestinal physiology and hepatic metabolism

    Författare :Mattias Bergentall; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microbiota; metabolism;

    Sammanfattning : The gut microbiota, a complex and dynamic community of microbes in the mammalian gut, has coevolved with us for ample time providing mutual benefits. However, mechanistic knowledge of these has been limited, but are now becoming increasingly clear. LÄS MER

  5. 4. Novel factors affecting clearance of triacylglycerol-rich lipoproteins from blood

    Författare :Stefan K Nilsson; Gunilla Olivecrona; Aivar Lookene; Ko Willems van Dijk; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipoprotein; triacylglycerol; apolipoprotein A-V; ANGPTL; Cardiovascular medicine; Kardiovaskulär medicin; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Apolipoprotein (apo) A-V is the most recently discovered member of a protein family responsible for the structure and metabolic fate of plasma lipoproteins. While most of the apolipoproteins are well characterized with regard to structure, interactions and function, the role of apoA-V is not well understood. LÄS MER

  7. 5. Foxf2 and Foxc2, two transcription factors that regulate adipocyte metabolism

    Författare :Rickard Westergren; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; forkhead genes; insulin signaling; glucose metabolism; adipose tissue; angiogenesis; Foxc2; Foxf2; Irs1; insulin resistance; Ang-2;

    Sammanfattning : Type 2 diabetes is the most common metabolic disorder today and has reached epidemic proportions in many countries. Diet-induced insulin resistance plays a central role in the development of type 2 diabetes. LÄS MER