Sökning: "anergy"

Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet anergy.

1. 1. Tolerance and Immunity: Opposite Outcomes of Microbial Antigen Stimulation

   Författare :Lena Eroukhmanoff; Immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TLR2; Tolerance; quinoline-3-carboxamide; Anergy; Foxp3; iNOS; IFN-β; CD4 splenic DCs;

   Sammanfattning : The immune system is remarkable in many ways. It exerts immunity to defend us from foreign pathogens, while it is also responsible for maintaining tolerance to avoid autoimmune diseases and allergy. This thesis includes three separate papers concerning both tolerance and immunity. LÄS MER

3. 2. Designing Energy-Sensitive Interactions : Conceptualising Energy from the Perspective of Electric Cars

   Författare :Anders Lundström; Jan Gulliksen; Kristina Höök; Cristi Bogdan; Ron Wakkary; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Interaction design; Electric vehicles; Range anxiety; Energy management; Battery management; Intergy; Exergy; Anergy; Energy-Sensitive Interactions; Energy dynamics; Energy compromises; Empowerment; Resourceful interaction; Människa-datorinteraktion; Human-computer Interaction;

   Sammanfattning : As technology is increasingly used in mobile settings, energy and battery management is becoming a part of everyday life. Many have experienced how quickly a battery can be depleted in a smartphone, laptop or electric cars, sometimes causing much distress. LÄS MER

4. 3. Activation of murine cytotoxic cells with interelukin-2 and the bacterial superantigen staphylococcal entertoxin A

   Författare :Hans Belfrage; Lund Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; transplantation; serology; Immunology; cytokine; tolerance; LAK; NK; serologi; CTL; Staphylococcal enterotoxin A; SEA; Interleukin-2; murine; deletion; anergy;

   Sammanfattning : Natural killer (NK) cells and T lymphocytes are the major effector cells that can recognize and kill tumor cells. NK cells have a constitutive cytotoxic activity and kill a wide spectrum of tumor cells while T cells recognize specific tumor antigens and need to be activated through their TCR to differentiate into cytotoxic T lymphocyte (CTL) killers or T helper cells. LÄS MER

5. 4. Regulatory mechanisms controlling T cell activity

   Författare :Anette Sundstedt; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; T cell superantigen anergy interleukin-2 transcription factor cytotoxicity; serology; Immunology; Immunologi; serologi;

   Sammanfattning : This thesis is based on work studying the immunoregulatory mechanisms that govern the balance between activation and inactivation of T lymphocytes. Most of the work has been carried out in an experimental system using a T cell receptor (TCR-Vb3) transgenic mouse strain to obtain a homogenous T-cell population and utilizing the properties of bacterial superantigens to induce T cell responses and unresponsiveness in vivo. LÄS MER

7. 5. CNS-Targeted Cell Therapy for Multiple Sclerosis

   Författare :Moa Fransson; Angelica Loskog; Tomas Olsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAR; Targeting; Suppressive cells; Foxp3; Tregs; Clinical immunology; Klinisk immunologi; Immunologi; Immunology;

   Sammanfattning : Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS). In the current thesis, we have preformed an immunological investigation of patients with MS and developed an immunosuppressive cell therapy that could be beneficial for these patients. LÄS MER