Sökning: "androgen receptor gene polymorphism"
Visar resultat 1 - 5 av 16 avhandlingar innehållade orden androgen receptor gene polymorphism.
1. Functional characterisation of the CAG polymorphism in the androgen receptor- in vitro and in vivo
Sammanfattning : The androgen receptor (AR) is the mediator of androgen actions. In the AR coding region there is a polymorphic CAG repeat encoding a stretch of the amino acid glutamine (Q). The repeat length modulates receptor activity and is normally distributed between 10-30 CAG with a median length of 22 repeats in white men. LÄS MER
2. THE ANDROGEN RECEPTOR GGN POLYMORPHISM. Genetic and functional analyses
Sammanfattning : Male sex development and reproductive function is regulated by androgens acting via the androgen receptor (AR). The AR harbours two polymorphic repeats of CAG and GGN triplets, encoding glutamines and glycines, respectively. LÄS MER
3. Polymorphism in sex steroid-related genes. Effects on hormone levels and behavior
Sammanfattning : Genetic factors are important for variations between individuals with respect to most humantraits and diseases. Sex steroids are of profound importance for reproduction, metabolism,cardiovascular function and bone formation. They are potent regulators of their ownsynthesis as well as of that of other hormones, including prolactin. LÄS MER
4. Genetic, environmental and life-style effects on androgen receptor function
Sammanfattning : Androgens regulate male reproductive function and their effects are mediated through the androgen receptor (AR). The AR gene contains a polymorphic CAG repeat, encoding a stretch of glutamines, affecting the transcriptional activity of the AR. LÄS MER
5. Studies of hyperandrogenicity and the metabolic syndrome in premenopausal women
Sammanfattning : An androgenic sex hormone profile appears to be a typical feature of the metabolic syndrome (MetS) and a powerful risk factor for the development of type 2 diabetes in women. The causes of relative hyperandrogenicity (HA) are not clearly defined. LÄS MER