Sökning: "androgen activity"
Visar resultat 6 - 10 av 59 avhandlingar innehållade orden androgen activity.
6. Characterization of Impaired Glucose Tolerance - Insulin Sensitivity, Islet Function and Metabolic Risk Factors
Sammanfattning : This thesis presents a three-year prospective study on metabolic characteristics of impaired glucose tolerance (IGT) and the regulation of insulin sensitivity versus islet function in relation to changes in glucose tolerance. 108 non-diabetic women aged 57-58 years were randomly selected from a population of women born in 1935 with a high prevalence of IGT. LÄS MER
7. Hormonal Regulation of the Human CYP27A1 and CYP7B1 Genes
Sammanfattning : CYP27A1 and CYP7B1 are widely expressed in various human tissues and are two key enzymes involved in the pathways for conversion of cholesterol to bile acids. Also, CYP27A1 is involved in bioactivation of vitamin D3 and CYP7B1 plays a role in 7alpha-hydroxylation of dehydroepiandrosterone and other steroids. LÄS MER
8. A step forward in using QSARs for regulatory hazard and exposure assessment of chemicals
Sammanfattning : According to the REACH regulation chemicals produced or imported to the European Union need to be assessed to manage the risk of potential hazard to human health and the environment. An increasing number of chemicals in commerce prompts the need for utilizing faster and cheaper alternative methods for this assessment, such as quantitative structure-activity or property relationships (QSARs or QSPRs). LÄS MER
9. The role of the prostate in androgen metabolism
Sammanfattning : The androgenic steroid hormones are essential for the physiological development of the prostate gland and are also implicated in pathological processes such as benign prostatic hyperplasia and prostate cancer. The systemic effect of endocrine activity in the prostate gland has so far been considered of minor importance. LÄS MER
10. Genetics of androgen disposition : implications for doping tests
Sammanfattning : Anabolic androgenic steroids (AAS) are derivatives of testosterone. Doping with AAS is a severe challenge to the vision, moral and ethics in sports and has also become an increasing problem in society. Testosterone abuse is conventionally assessed by the urinary testosterone glucuronide/ epitestosterone glucuronide (T/E) ratio, levels above 4. LÄS MER