Sökning: "androgen ablation"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden androgen ablation.

  1. 1. Androgen controlled regulatory systems in prostate cancer : potential new therapeutic targets and prognostic markers

    Författare :Peter Hammarsten; Anders Bergh; Stina Häggström Rudolfsson; Pernilla Wikström; Sten Nilsson; Umeå universitet; []
    Nyckelord :AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; prostate cancer; angiogenesis; human biopsy; androgen ablation; castration; prognostic marker; prognostic factor; growth control; VEGF; vascular endothelial growth factor; EGFR; epidermal growth factor receptor; pEGFR; phosphorylated EGFR; phosphorylated epidermal growth factor receptor; Pathology; Patologi;

    Sammanfattning : BACKGROUND: Prostate cancer is by far the most common cancer among Swedish men. Some patients have an aggressive lethal disease, but the majority of affected men have long expected survival. Unfortunately, the diagnostic tools available are insufficient in predicting disease aggressiveness. Novel prognostic markers are therefore urgently needed. LÄS MER

  2. 2. Early effects of castration therapy in non-malignant and malignant prostate tissue

    Författare :Nina Ohlson; Pernilla Wikström; Anders Bergh; Pär Stattin; Marja Nevalainen; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; human biopsies; androgen ablation; stroma; epithelium; micro-dissection; PSA; IGF-1; IGF-R1; AR; Pathology; Patologi;

    Sammanfattning : Early Effects of Castration Therapy in Non-malignant and Malignant Prostate Tissue BACKGROUND. Androgen ablation, the standard treatment for advanced prostate cancer, results in increased apoptosis, decreased cell proliferation and subsequent involution of the prostate gland. LÄS MER

  3. 3. A functional genomics approach to study prostate disorders

    Författare :See-Tong Pang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Prostate cancer; BPH; androgen; DNA microarray; gene expression; CGH; SKY; oxidative stress.;

    Sammanfattning : Benign prostate hyperplasia (BPH) and prostate cancer (PCa) are the two most common prostatic disorders in elderly man. Currently, the causes of both diseases are still not clear. However, androgen is a well recognized risk factor for both diseases. LÄS MER

  4. 4. Neoadjuvant hormone treatment in localized prostate cancer : A clinical and histopathological study

    Författare :Magnus Hellström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Localized prostate cancer; radical prostatectomy; neo-adjuvant androgen deprivation; GnRH-agonist; histopathology; immunohistochemistry; image analysis; cancer volume; DNA ploidy patterns; PSA in serum; follow-up; prognosisStockholm 1996;

    Sammanfattning : Neoadjuvant hormone treatment in localized prostate cancer, a clinical andhistopathological studyMagnus Hellström, Karolinska Institute Danderyd Hospital, Division of Urology, S-182 88 Danderyd, SwedenSurgical treatment of localized prostate cancer may be hampered by the spread of cancer through theprostate capsule and in the surgical margins. The prostate is dependent on androgen hormones for itsgrowth and function. LÄS MER

  5. 5. Smad7 in TGF-β Signalling

    Författare :Greger Brodin; Stefan Karlsson; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; TGF-β; Smad7; Prostate; Transcription; Gene targeting; Onkologi; Oncology; Onkologi; molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Members of the transforming growth factor-β (TGF-β) superfamily of growth and differentiation factors regulate a vast array of biological functions in the adult, and are of great importance in governing cell fate determination and patterning in the developing embryo. The TGF-β signal is propagated intracellularly by Smad proteins resulting in transcriptional responses. LÄS MER