Sökning: "and small leucine-rich repeat proteoglycan."

Hittade 5 avhandlingar innehållade orden and small leucine-rich repeat proteoglycan..

  1. 1. Fibromodulin and chondroadherin in connective tissue homeostasis

    Författare :Viveka Tillgren; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Collagen; integrin; cell surface proteoglycan; extracellular matrix; and small leucine-rich repeat proteoglycan.;

    Sammanfattning : Connective tissue contains a prominent extracellular matrix (ECM), which provides for physiological and mechanical properties. Intra- and inter-molecular interactions between proteins in this ECM provide for the formation of molecular networks. These interactions determine the shape of the tissue as well as cell behavior. LÄS MER

  3. 2. Collagen VI - Molecular Assembly and Interactions

    Författare :Charlotte Wiberg; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical biology; extracellular matrix; glycosaminoglycan; proteoglycan; collagen; biglycan; decorin; Klinisk biologi;

    Sammanfattning : The extracellular matrix plays an integral role in tissue remodeling and development and it defines the different mechanical properties of a variety of connective tissues. Its complexity in composition and the details in organization has only been partly elucidated. LÄS MER

  4. 3. Complement in Disease - Extracellular Proteins as Complement Regulators

    Författare :Kaisa Happonen; Malmö Proteinkemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; joint disease; Complement; proteoglycan; cancer;

    Sammanfattning : Complement activation occurs during inflammatory joint diseases such as rheumatoid arthritis (RA) and is thought to contribute to the chronic inflammation observed within the joints. Previous studies have shown that certain cartilage components of the small leucine-rich repeat protein (SLRP)-family regulate complement activity, thereby possibly contributing to disease progression. LÄS MER

  5. 4. Fibromodulin and Dystrophin in Atherosclerosis: Novel roles for extracellular matrix in plaque development

    Författare :Annelie Shami; Kärlväggsbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atherosclerosis; fibromodulin; dystrophin; carotid artery; lipid accumulation; restenosis; plaque;

    Sammanfattning : Cardiovascular disease represents nearly half the cases of noncommunicable diseases worldwide and is the leading global cause of death. The main underlying cause is atherosclerosis, and in atherosclerotic plaque progression the structure, composition and integrity of a dynamic extracellular matrix (ECM) is one very important factor. LÄS MER

  7. 5. The collagen fibrillar network: Sequential degradation of its constituents by tissue metalloproteinases

    Författare :Terrence Heathfield; Enheten för led- och mjukvävnadsforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolism; Metabolism; Biochemistry; collagen; fibromodulin; cartilage; osteoarthritis; Biokemi;

    Sammanfattning : The cartilage matrix is made up of a fibrillar meshwork comprising type II collagen and other associated proteins. One main function of this network is to retain the large aggregating proteoglycan, aggrecan, a vital component in the regulation of fluid flux in cartilage. LÄS MER