Sökning: "ancient dna"

Visar resultat 1 - 5 av 64 avhandlingar innehållade orden ancient dna.

1. 1. Methodology and Infrastructure for Statistical Computing in Genomics : Applications for Ancient DNA

   Författare :Kristiina Ausmees; Carl Nettelblad; Mattias Jakobsson; Flora Jay; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; statistical computing; genotype imputation; ancient DNA; deep learning; dimensionality reduction; genetic clustering; distributed computing; Scientific Computing; Beräkningsvetenskap;

   Sammanfattning : This thesis concerns the development and evaluation of computational methods for analysis of genetic data. A particular focus is on ancient DNA recovered from archaeological finds, the analysis of which has contributed to novel insights into human evolutionary and demographic history, while also introducing new challenges and the demand for specialized methods. LÄS MER

3. 2. Uncovering the Past through ancient DNA : The Fate and Legacy of the last hunter-gatherers in Western Europe and Northwestern Africa

   Författare :Luciana G. Simões; Mattias Jakobsson; Torsten Günther; Cristina Valdiosera; Emma Svensson; Martin Sikora; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; human evolution; archaeogenomics; ancient DNA; population genetics; hunter-gatherer; Populationsbiologi; Population Biology; Genetik; Genetics;

   Sammanfattning : The genetic analysis of ancient human remains has revolutionized the study of human history, opening a direct window onto the demographic and evolutionary events that shaped our species' past. I use state-of-the-art ancient DNA methodologies, from sample collection and DNA extraction to data analysis, to study the ancient past of the western Mediterranean region, where climate does not favour DNA preservation. LÄS MER

4. 3. Ancient genomics of Baltic seals : Insights on the past Baltic grey seal and harp seal populations

   Författare :Maiken Hemme Bro-Jørgensen; Kerstin Lidén; Morten Tange Olsen; Aikaterini Glykou; Olle Karlsson; Stockholms universitet; []
   Nyckelord :HUMANIORA; HUMANITIES; Ancient DNA; Baltic Sea; DNA preservation; extinction; mitogenome; seal hunting; sex identification; arkeologi med inriktning mot laborativ arkeologi; Scientific Archaeology;

   Sammanfattning : This thesis aims to study and describe the ancient populations of grey and harp seals in the Baltic Sea, and to present new methodological approaches for general use in ancient DNA studies.The dissertation is comprised of five studies: a review of the use of paleogenetics in studying ancient human-marine mammal interactions; a method paper investigating patterns of DNA preservation in ancient pinniped samples; a method paper presenting a genetic sex identification method for ancient pinnipeds; a population genomic study of the Baltic grey seal; and a population genomic study of the now extinct Baltic harp seal. LÄS MER

5. 4. Application of Mitochondrial DNA Analysis in Contemporary and Historical Samples

   Författare :Maria Lembring; Marie Allen; Niels Morling; Uppsala universitet; []
   Nyckelord :Forensic genetics; Mitochondrial DNA; HVI HVII; Population database; Haplotype; Haplogroup; Ancient DNA; Historical DNA samples; skeletal remains; Vasa museum; Medieval samples; Copernicus; Göring; Genetik; Genetics;

   Sammanfattning : The mitochondrion is a tiny organelle that is the power supplier of the cell and vital to the functioning of the body organs. Additionally it contains a small circular genome of about 16 kb, present in many copies which makes the mitochondrial DNA more viable than nuclear DNA. LÄS MER

7. 5. Molecular Palaeopathology : Ancient DNA analyses of the bacterial diseases tuberculosis and leprosy

   Författare :Emilia Nuorala; Kerstin Lidén; Ingrid Ekenman; Marie Allen; Stockholms universitet; []
   Nyckelord :HUMANIORA; HUMANITIES; molecular palaeopathology; ancient DNA; disease; bacteria; tuberculosis; leprosy; Archaeology subjects; Arkeologiämnen;

   Sammanfattning : This thesis “Molecular Palaeopathology. Ancient DNA analyses of the bacterial diseases tuberculosis and leprosy” deals with molecular palaeopathology, i.e. in this case the use of molecular methods to analyse ancient bacterial DNA in order to get further knowledge of diseases in ancient times. LÄS MER